活性氧在高血压中的作用：对孕鼠慢性抗血管生成因子（sFlt-1）过多的反应。
Role of reactive oxygen species during hypertension in response to chronic antiangiogenic factor (sFlt-1) excess in pregnant rats.
机构信息
Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, USA.
出版信息
Am J Hypertens. 2011 Jan;24(1):110-3. doi: 10.1038/ajh.2010.180. Epub 2010 Aug 19.
Abstract
BACKGROUND
Preeclampsia is associated with increased levels of reactive oxygen species (ROS) and the antiangiogenic factor, soluble fms-like tyrosine kinase-1 (sFlt-1). Moreover, recent studies have indicated that chronic sFlt-1 excess causes hypertension in pregnant animals. The purpose of this study was to evaluate the role of ROS in mediating sFlt-1-induced hypertension in the pregnant rat.
METHODS
Mean arterial pressure (MAP), and plasma sFlt-1 and tissue ROS levels were measured in the following groups: (i) pregnant controls; (ii) sFlt-1-treated pregnant rats; (iii) Tempol-treated pregnant rats; (iv) sFlt-1- and Tempol-treated pregnant rats.
RESULTS
MAP increased from 104 ± 2 mm Hg in pregnant control rats to 118 ± 3 mm Hg (P = 0.002) in sFlt-1-infused rats. Basal and nicotinamide adenine dinucleotide phosphate (NADPH)-stimulated levels of tissue ROS were increased in response to excess sFlt-1 during pregnancy. Pretreatment with Tempol attenuated oxidative stress and hypertension in response to sFlt-1.
CONCLUSIONS
ROS play an important role in mediating hypertension in response to chronic sFlt-1 excess during pregnancy.
摘要
背景
子痫前期与活性氧（ROS）和抗血管生成因子可溶性 fms 样酪氨酸激酶-1（sFlt-1）水平升高有关。此外，最近的研究表明，慢性 sFlt-1 过量会导致怀孕动物的高血压。本研究旨在评估 ROS 在介导 sFlt-1 诱导的怀孕大鼠高血压中的作用。
方法
测量以下各组的平均动脉压（MAP）、血浆 sFlt-1 和组织 ROS 水平：（i）怀孕对照组；（ii）sFlt-1 处理的怀孕大鼠；（iii）Tempol 处理的怀孕大鼠；（iv）sFlt-1 和 Tempol 处理的怀孕大鼠。
结果
MAP 从怀孕对照组大鼠的 104 ± 2 mmHg 增加到 sFlt-1 输注大鼠的 118 ± 3 mmHg（P = 0.002）。妊娠期间过量的 sFlt-1 导致组织 ROS 的基础和烟酰胺腺嘌呤二核苷酸磷酸（NADPH）刺激水平增加。Tempol 预处理可减轻对 sFlt-1 反应的氧化应激和高血压。
结论
ROS 在介导慢性 sFlt-1 过量引起的妊娠高血压中起重要作用。
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