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本文引用的文献

1
Uncertainty in the perioperative management of high-risk cutaneous squamous cell carcinoma among Mohs surgeons.莫氏外科医生对高危皮肤鳞状细胞癌围手术期管理的不确定性。
Arch Dermatol. 2010 Nov;146(11):1225-31. doi: 10.1001/archdermatol.2010.323.
2
Reduction in the incidence of squamous cell carcinoma in solid organ transplant recipients treated with cyclic photodynamic therapy.环式光动力疗法治疗实体器官移植受者可降低鳞状细胞癌发病率。
Dermatol Surg. 2010 May;36(5):652-8. doi: 10.1111/j.1524-4725.2009.01384.x. Epub 2009 Nov 4.
3
Diameter of involved nerves predicts outcomes in cutaneous squamous cell carcinoma with perineural invasion: an investigator-blinded retrospective cohort study.受累神经的直径可预测伴有神经周围侵犯的皮肤鳞状细胞癌的结局：一项研究者设盲的回顾性队列研究。
Dermatol Surg. 2009 Dec;35(12):1859-66. doi: 10.1111/j.1524-4725.2009.01354.x.
4
Mohs versus traditional surgical excision for facial and auricular nonmelanoma skin cancer: an analysis of cost-effectiveness.莫氏手术与传统手术切除治疗面部和耳部非黑色素瘤皮肤癌的成本效益分析
Dermatol Surg. 2009 Nov;35(11):1776-87. doi: 10.1111/j.1524-4725.2009.01291.x. Epub 2009 Sep 8.
5
A relative value unit-based cost comparison of treatment modalities for nonmelanoma skin cancer: effect of the loss of the Mohs multiple surgery reduction exemption.非黑色素瘤皮肤癌治疗方式基于相对价值单位的成本比较：莫氏多次手术减免优惠取消的影响
J Am Acad Dermatol. 2009 Jul;61(1):96-103. doi: 10.1016/j.jaad.2008.07.047.
6
Conversion from calcineurin inhibitors to sirolimus reduces vascularization and thickness of post-transplant cutaneous squamous cell carcinomas.从钙调神经磷酸酶抑制剂转换为西罗莫司可减少移植后皮肤鳞状细胞癌的血管生成和厚度。
Anticancer Res. 2009 Jun;29(6):1927-32.
7
Innovative 19-minute rapid cytokeratin immunostaining of nonmelanoma skin cancer in Mohs micrographic surgery.在莫氏显微外科手术中对非黑色素瘤皮肤癌进行创新的19分钟快速细胞角蛋白免疫染色。
Dermatol Surg. 2009 Jul;35(7):1050-6. doi: 10.1111/j.1524-4725.2009.01182.x. Epub 2009 May 15.
8
Cetuximab therapy of metastasizing cutaneous squamous cell carcinoma in a patient with severe recessive dystrophic epidermolysis bullosa.西妥昔单抗治疗一名患有严重隐性营养不良性大疱性表皮松解症患者的转移性皮肤鳞状细胞癌。
Dermatology. 2009;219(1):80-3. doi: 10.1159/000218714. Epub 2009 May 13.
9
Surgical monotherapy versus surgery plus adjuvant radiotherapy in high-risk cutaneous squamous cell carcinoma: a systematic review of outcomes.高危皮肤鳞状细胞癌的手术单药治疗与手术联合辅助放疗：结局的系统评价
Dermatol Surg. 2009 Apr;35(4):574-85. doi: 10.1111/j.1524-4725.2009.01095.x.
10
Phase III study of gefitinib compared with intravenous methotrexate for recurrent squamous cell carcinoma of the head and neck [corrected].吉非替尼与静脉注射甲氨蝶呤治疗复发性头颈部鳞状细胞癌的III期研究[校正后]
J Clin Oncol. 2009 Apr 10;27(11):1864-71. doi: 10.1200/JCO.2008.17.0530. Epub 2009 Mar 16.

高危皮肤鳞状细胞癌的管理

Management of high-risk cutaneous squamous cell carcinoma.

作者信息

Jennings Lorraine, Schmults Chrysalyne D

机构信息

Mohs Micrographic Surgery Center, Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

出版信息

J Clin Aesthet Dermatol. 2010 Apr;3(4):39-48.

PMID:20725546
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2921745/
Abstract

Cutaneous squamous cell carcinoma is an increasing public health concern, representing the second most common cancer in the United States. High-risk cutaneous squamous cell carcinoma represents a subgroup of this disease, where patients are at higher risk of metastasis and death. To date, there are no accepted criteria for defining or managing these patients. This review discusses the current state of knowledge of high-risk cutaneous squamous cell carcinoma and outlines reasonable management strategies based on available data.

摘要

皮肤鳞状细胞癌日益引起公众对健康的关注，是美国第二大常见癌症。高危皮肤鳞状细胞癌是该疾病的一个亚组，这类患者发生转移和死亡的风险更高。迄今为止，尚无公认的定义或管理这些患者的标准。本综述讨论了高危皮肤鳞状细胞癌的当前知识状况，并根据现有数据概述了合理的管理策略。