Cohen Joel L
Department of Dermatology, University of Colorado, Denver; AboutSkin Dermatology and DermSurgery, Englewood, Colorado.
J Clin Aesthet Dermatol. 2010 Jun;3(6):39-44.
Actinic keratosis is responsible for more than eight million visits to dermatologists and primary care physicians annually. Actinic keratosis, the result of chronic sun damage to the skin, is closely linked to nonmelanoma skin cancer, both histologically and pathophysiologically. Clinical evidence shows that not only does actinic keratosis have the potential to progress and transform into nonmelanoma skin cancer, but it also may in fact be an early stage of cancer. The treatment of actinic keratosis is evolving from a "treat-as-you-go" strategy to a more preventive approach to curtail the potential emergence of nonmelanoma skin cancer. As the interrelationship between actinic keratosis and nonmelanoma skin cancer, squamous cell carcinoma, and basal cell carcinoma continues to strengthen, treating actinic keratosis as part of a preventive strategy to reduce nonmelanoma skin cancer is coming to the forefront. The following review of the relationship between actinic keratosis and nonmelanoma skin cancer discusses the rationale for early actinic keratosis treatment to prevent or reduce nonmelanoma skin cancer occurrence.
光化性角化病每年导致超过800万人就诊于皮肤科医生和初级保健医生。光化性角化病是皮肤长期受阳光损伤的结果，在组织学和病理生理学上都与非黑素瘤皮肤癌密切相关。临床证据表明，光化性角化病不仅有可能进展并转变为非黑素瘤皮肤癌，实际上它可能还是癌症的早期阶段。光化性角化病的治疗正从“出现就治疗”的策略演变为更具预防性的方法，以减少非黑素瘤皮肤癌的潜在发生。随着光化性角化病与非黑素瘤皮肤癌、鳞状细胞癌和基底细胞癌之间的相互关系不断加强，将光化性角化病作为预防非黑素瘤皮肤癌的策略的一部分进行治疗正变得日益重要。以下对光化性角化病与非黑素瘤皮肤癌之间关系的综述讨论了早期治疗光化性角化病以预防或减少非黑素瘤皮肤癌发生的基本原理。
