Institute for Technology Research and Innovation, Deakin University, Waurn Ponds, Victoria 3217, Australia.
J Biomed Mater Res A. 2010 Dec 1;95(3):766-73. doi: 10.1002/jbm.a.32903.
The morphology of nanomaterials significantly affects their physical, chemical, and biological properties. In the present study, nano-hydroxyapatite coatings with different morphologies were produced on the surface of a titanium-niobium shape memory alloy via a hydrothermal process. The effect of the nano-hydroxyapatite coatings on the in vitro proliferation of SaOS-2 osteoblast-like cells was investigated. Factors including crystallinity, surface micro-roughness, and surface energy of the nano-hydroxyapatite coatings were discussed. Results show that in vitro proliferation of the osteoblast-like cells was significantly enhanced on the nano-hydroxyapatite-coated titanium-niobium alloy compared to the titanium-niobium alloy without coating. The cell numbers on the nano-hydroxyapatite-coated titanium-niobium alloy changed consistently with the surface energy of the hydroxyapatite coatings. This study suggests that surface energy as a characteristic parameter influencing the in vitro proliferation of osteoblast-like cells was predominant over the crystallinity and surface micro-roughness of the nano-hydroxyapatite coatings.
纳米材料的形态对其物理、化学和生物特性有显著影响。本研究通过水热法在钛铌形状记忆合金表面制备了具有不同形态的纳米羟基磷灰石涂层。研究了纳米羟基磷灰石涂层对 SaOS-2 成骨样细胞体外增殖的影响。探讨了纳米羟基磷灰石涂层的结晶度、表面微观粗糙度和表面能等因素。结果表明，与未涂层的钛铌合金相比，纳米羟基磷灰石涂层钛铌合金上成骨样细胞的体外增殖明显增强。成骨样细胞数量随羟基磷灰石涂层表面能的变化而一致。本研究表明，作为影响成骨样细胞体外增殖的特征参数，表面能比纳米羟基磷灰石涂层的结晶度和表面微观粗糙度更为重要。
