Cheng Yibin, Jin Yinlong, Ma Feng, Liang Chaoke, Liu Ya, Bian Jianchao, Li Ping, Gao Sujuan
Institute for Environmental Health and Related Product Safety, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Wei Sheng Yan Jiu. 2010 Jul;39(4):483-5, 490.
To know the relationship between selenium exposure level and cognitive function and its influencing factors in rural elderly people.
A cross-sectional survey of 200 local rural elderly people were conducted by using dietary questionnaire and six cognitive questionnaires. The local environment samples were collected including food and nail and blood sample of study individuals. The trace amount of selenium were determined with 2, 3-diaminonaphthalenet fluorometric determination. Multiple stepwise regression was used to examine the association between selenium exposure level and the composite Z score adjusting for age, gender, education, and other factors that might influence the cognitive scores.
There were significant positively relationships between three selenium exposure indexes. The results showed that food selenium intake level and blood selenium level could significantly affected the Z score after adjusting age, education and other factors by using multiple stepwise regression analysis (P < 0.001).
Lower selenium exposure level maybe associated with lower cognitive function in rural elderly people.
了解农村老年人硒暴露水平与认知功能的关系及其影响因素。
采用饮食问卷和六种认知问卷对200名当地农村老年人进行横断面调查。采集当地环境样本，包括研究对象的食物、指甲和血液样本。采用2,3-二氨基萘荧光法测定微量硒。采用多元逐步回归分析，在调整年龄、性别、教育程度和其他可能影响认知得分的因素后，检验硒暴露水平与综合Z评分之间的关联。
三个硒暴露指标之间存在显著正相关。多元逐步回归分析结果显示，在调整年龄、教育程度等因素后，食物硒摄入量水平和血硒水平可显著影响Z评分（P < 0.001）。
农村老年人较低的硒暴露水平可能与较低的认知功能有关。
