Drozd N N, Kuznetsova S A, Miftakhova N T, Makarov V A, Vasil'eva N Iu, Levdanskiĭ A V, Butylkina A I
Eksp Klin Farmakol. 2010 Jun;73(6):14-8.
We have investigated in vitro the anticoagulant (AC) activity of proanthocyanidins from the bark of birch, cedar, spruce, pine, and larch; sulfated arabinogalantan and dihydroquercetin from larch wood; extracts from birch, cedar, and spruce; microcrystalline cellulose (MCC) from aspen and fir wood and wheat straw; and methylcellulose (MC) from aspen wood. The AC properties of the investigated substances are related mostly to their antithrombin activity. The AC activity increases with the content of sulfur in MCC of wheat straw, MC of aspen wood, and arabinogalañtan of larch wood. The maximum AC activity was observed in samples of sulfated MCC from fir wood and wheat straw. Their antithrombin activity (134 +/- 8 and 96 +/- 6, respectively) is worth of carrying out model tests in vivo.
我们已经在体外研究了桦树、雪松、云杉、松树和落叶松树皮中的原花青素；落叶松木中的硫酸化阿拉伯半乳聚糖和二氢槲皮素；桦树、雪松和云杉的提取物；白杨、冷杉木材和麦秸中的微晶纤维素（MCC）；以及白杨木中的甲基纤维素（MC）的抗凝（AC）活性。所研究物质的AC特性主要与其抗凝血酶活性有关。AC活性随着麦秸MCC、白杨木MC和落叶松木阿拉伯半乳聚糖中硫含量的增加而增加。在来自冷杉木材和麦秸的硫酸化MCC样品中观察到最大AC活性。它们的抗凝血酶活性（分别为134±8和96±6）值得进行体内模型试验。
