Lanzhou University, State Key Laboratory of Applied Organic Chemistry and Institute of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Lanzhou, People's Republic of China.
IET Nanobiotechnol. 2010 Sep;4(3):72-6. doi: 10.1049/iet-nbt.2009.0017.
The well-defined thermo-responsive polymeric nanocapsules were prepared by the one-pot approach via the surface-initiated atom transfer radical copolymerisation of N-isopropyl acrylamide (NIPAM) and N, N-methylenebisacylamide (MBA) from the silica nanoparticle templates after the silica templates were removed by hydrofluoric acid (HF). The diameter of the polymeric nanocapsules is in the range of 20-40 nm, characterised by transmission electron microscopy (TEM). The temperature-induced dimensional change of the thermo-responsive polymeric nanocapsules was investigated by dynamic light scattering (DLS) in aqueous solutions. The intelligent thermo-responsive polymeric nanocapsules are expected to be used for the controlled release of sensitive molecules, such as enzymes, proteins or DNA, by changing the environmental temperature.
通过在 HF 去除二氧化硅模板后，从二氧化硅纳米颗粒模板上通过表面引发原子转移自由基共聚 N-异丙基丙烯酰胺（NIPAM）和 N，N-亚甲基双丙烯酰胺（MBA），制备了具有明确形态的温敏聚合物纳米胶囊。聚合物纳米胶囊的直径在 20-40nm 范围内，通过透射电子显微镜（TEM）进行了表征。通过动态光散射（DLS）在水溶液中研究了温敏聚合物纳米胶囊的温度诱导的尺寸变化。通过改变环境温度，智能温敏聚合物纳米胶囊有望用于控制敏感分子（如酶、蛋白质或 DNA）的释放。
