Department of Endocrinology, Jilin University, Changchun, 130021, China.
Radiat Res. 2010 Oct;174(4):467-79. doi: 10.1667/RR1980.1.
In this study we investigated the effect of repeated low-dose radiation exposure (75 mGy X ray) on skin wound healing in a rat model of diabetes. A skin wound was made on the backs of diabetic and age-matched control rats 60 days after diabetes was induced by a single injection of streptozotocin. Rats with skin wounds were immediately treated with whole-body radiation daily for 5, 10 or 15 days with a 2-day break every 5 days. Wound size was estimated 5, 10 and 15 days after wound formation. Repeated exposure of diabetic rats to low-dose radiation significantly accelerated skin wound healing compared to the nonirradiated diabetic group. Furthermore, low-dose radiation-induced improvement in healing was associated with increases in bone marrow and circulating CD31(+)/CD34(+) stem cells, vessel regeneration and cell proliferation in the wound tissue, and matrix metalloproteinase 2 and 9 expression. Therefore, we conclude that the acceleration of wound healing in diabetic rats by repeated exposure to low-dose radiation is associated with stimulation of bone marrow stem cell proliferation and peripheral mobilization.
在这项研究中，我们调查了重复低剂量辐射（75 mGy X 射线）对糖尿病大鼠模型皮肤伤口愈合的影响。在通过单次链脲佐菌素注射诱导糖尿病 60 天后，在糖尿病和年龄匹配的对照大鼠的背部制造皮肤伤口。在形成伤口后 5、10 和 15 天，对带有皮肤伤口的大鼠每天进行全身辐射治疗 5、10 或 15 天，每 5 天休息 2 天。伤口形成后 5、10 和 15 天估计伤口大小。与未辐照的糖尿病组相比，糖尿病大鼠反复暴露于低剂量辐射可显著加速皮肤伤口愈合。此外，低剂量辐射诱导的愈合改善与骨髓和循环 CD31(+)/CD34(+)干细胞、血管再生和伤口组织中的细胞增殖以及基质金属蛋白酶 2 和 9 表达的增加有关。因此，我们得出结论，重复低剂量辐射暴露加速糖尿病大鼠的伤口愈合与刺激骨髓干细胞增殖和外周动员有关。
