印度班加罗尔献血者中慢性乙型肝炎病毒感染的危险因素。

Risk factors for chronic hepatitis B virus infection among blood donors in Bangalore, India.

作者信息

Jagannathan L, Chaturvedi M, Mudaliar S, Kamaladoss T, Rice M, Murphy E L

机构信息

Rotary TTK Blood Bank, Bangalore Medical Services Trust, Bangalore, India Harvard University School of Public Health, Boston, Massachusetts, USA.

出版信息

Transfus Med. 2010 Dec;20(6):414-20. doi: 10.1111/j.1365-3148.2010.01032.x. Epub 2010 Aug 18.

DOI:10.1111/j.1365-3148.2010.01032.x

PMID:20726953

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2957532/

Abstract

OBJECTIVES AND AIM

We performed a study of hepatitis B virus (HBV) risk factors among blood donors in Bangalore, India.

BACKGROUND

HBV infection is prevalent in India and poses a potential risk of transmission by blood transfusion, but studies of risk factors for hepatitis B surface antigen (HBsAg) carriage among Indian blood donors are lacking.

METHODS/MATERIALS: Using a case-cohort design, we enrolled 71 cases with repeatedly reactive HBsAg results and a cohort of 212 contemporaneous blood donors with unknown HBsAg status. Questionnaire data were analysed using multivariable logistic regression.

RESULTS

In our multivariate analysis controlling for age, HBsAg positivity was associated with repeat donor status (OR = 0·34, 95% CI 0·17-0·71 vs first-time donor status), residence outside Bangalore and Hosur (rural areas) (OR = 15·66, 95% CI 3·60-68·07vs Bangalore residence), having been a customer at a local barber shop (OR = 4·07, 95% CI 2·06-8·03), close contact with a person who had jaundice (OR = 13·64, 95% CI 3·71-50·24) and cigarette smoking (OR = 3·25, 95% CI 1·39-7·60).

CONCLUSION

In addition to recognised demographic risk factors, associations with patronage of local barbers and contact with jaundiced individuals suggest behavioural risk factors that could be adopted as exclusionary criteria for blood donation in India.

摘要

目的与目标

我们对印度班加罗尔献血者中的乙型肝炎病毒（HBV）风险因素进行了一项研究。

背景

HBV感染在印度很普遍，存在输血传播的潜在风险，但缺乏关于印度献血者中乙型肝炎表面抗原（HBsAg）携带风险因素的研究。

方法/材料：采用病例队列设计，我们纳入了71例HBsAg结果反复呈阳性的病例以及212名同期HBsAg状态未知的献血者组成的队列。使用多变量逻辑回归分析问卷数据。

结果

在我们控制年龄的多变量分析中，HBsAg阳性与重复献血者身份（比值比[OR]=0.34，95%置信区间[CI]为0.17 - 0.71，与首次献血者身份相比）、居住在班加罗尔和霍苏尔以外（农村地区）（OR = 15.66，95% CI为3.60 - 68.07，与居住在班加罗尔相比）、曾是当地理发店的顾客（OR = 4.07，95% CI为2.06 - 8.03）、与黄疸患者密切接触（OR = 13.64，95% CI为3.71 - 50.24）以及吸烟（OR = 3.25，95% CI为1.39 - 7.60）相关。