University Hospital Aachen, Department of Oral and Maxillofacial Surgery, Aachen, Germany.
Head Face Med. 2010 Aug 20;6:21. doi: 10.1186/1746-160X-6-21.
The goal of this study was to evaluate the somatic and psychological effects by means of QUALITY OF LIFE (QOL) of surgical treatment of patients with oral squamous cell carcinoma. The factors gender, age, nicotine consumption, and tumour stage were taken into consideration.
54 patients after surgical resection of oral squamous cell carcinomas (OSCC) were analysed from 01.09.2005 to 31.05.2008. Inclusion criteria for the study were: age at least 18 years, no indication or treatment of synchronous and metachronous tumours. German translations of the EORTC H&N-35 and EORTC QLQ-C-30 questionnaires, as well as a general socioeconomic patient history were used as measuring instruments. The questionnaires were completed independently by the patients. The answers were translated into scale values for statistical evaluation using appropriate algorithms.
Analysis of the EORTC-QLQ-C-30 questionnaires demonstrated a tendency of more negative assessment of emotional function among the female participants, and a more negative evaluation of social function among the male participants. Greater tumour sizes showed significantly lower bodily function (p = 0.018). While a smaller tumour size was significantly associated with lower cognitive functioning (p = 0.031). Other cofactors such as age, nicotine consumption, and tumour stage only showed a tendency to influence the quality of sleep and daily life.
The data obtained within this investigation demonstrated that gender had the most significant power on the subjectively perceived postoperative quality of life. This factor is important e.g. in preoperative decision making regarding immediate microvascular reconstruction after e.g. mandibular resection and therefore QOL assessment should become integral component of the care of patients with OSCC.
本研究旨在通过生活质量（QOL）评估手术治疗口腔鳞状细胞癌患者的躯体和心理影响。考虑了性别、年龄、尼古丁消耗和肿瘤分期等因素。
2005 年 9 月 1 日至 2008 年 5 月 31 日，分析了 54 例接受口腔鳞状细胞癌（OSCC）手术后的患者。该研究的纳入标准为：年龄至少 18 岁，无同步和异时性肿瘤的指征或治疗。使用 EORTC H&N-35 和 EORTC QLQ-C-30 问卷的德语翻译以及一般社会经济患者病史作为测量工具。问卷由患者独立完成。使用适当的算法将答案转换为量表值进行统计评估。
EORTC-QLQ-C-30 问卷分析表明，女性参与者的情绪功能评估更倾向于负面，男性参与者的社会功能评估更倾向于负面。较大的肿瘤大小显著降低身体功能（p=0.018）。而较小的肿瘤大小与认知功能降低显著相关（p=0.031）。其他协变量，如年龄、尼古丁消耗和肿瘤分期，仅表现出对睡眠和日常生活质量的影响趋势。
本研究获得的数据表明，性别对术后主观感知生活质量的影响最大。这个因素在例如下颌骨切除后立即进行微血管重建的术前决策中很重要，因此 QOL 评估应成为 OSCC 患者护理的一个组成部分。
