Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi 62, India.
Drug Discov Today. 2010 Nov;15(21-22):958-65. doi: 10.1016/j.drudis.2010.08.007. Epub 2010 Aug 17.
Self-emulsifying drug delivery systems are a vital tool in solving low bioavailability issues of poorly soluble drugs. Hydrophobic drugs can be dissolved in these systems, enabling them to be administered as a unit dosage form for per-oral administration. When such a system is released in the lumen of the gastrointestinal tract, it disperses to form a fine emulsion (micro/nano) with the aid of GI fluid. This leads to in situ solubilization of drug that can subsequently be absorbed by lymphatic pathways, bypassing the hepatic first-pass effect. This article presents an exhaustive account of various literature reports on diverse types of self-emulsifying formulations with emphasis on their formulation, characterization and in vitro analysis, with examples of currently marketed preparations.
自乳化药物传递系统是解决难溶性药物生物利用度低问题的重要工具。亲脂性药物可以溶解在这些系统中，从而可以将其作为口服给药的单位剂型给药。当这样的系统在胃肠道腔中释放时，它会在 GI 液的帮助下分散形成精细的乳液（微/纳米）。这导致药物的原位增溶，随后可以通过淋巴途径被吸收，绕过肝脏首过效应。本文全面介绍了各种关于不同类型自乳化制剂的文献报告，重点介绍了它们的制剂、特性和体外分析，并举例说明了目前市售的制剂。
