Department of Pediatrics, Washington University, St Louis, MO, USA.
Semin Pediatr Neurol. 2010 Sep;17(3):163-8. doi: 10.1016/j.spen.2010.06.010.
Seizures are more prevalent during the neonatal period than at any other time in the human lifespan. During early development, neonates are developmentally predisposed to excitatory neuronal activity increasing their susceptibility to seizures. Status epilepticus is poorly defined in this subpopulation with a lack of a consensus definition. In this review, we discuss the common etiologies of recurrent seizures in the newborn in addition to current trends on monitoring and treatment. Finally, we discuss the current evidence in both animal and human studies that indicate that neonatal seizures may be harmful to the immature brain with adverse long-term neurodevelopment outcomes.
癫痫发作在新生儿期比在人类生命的任何其他时间都更为普遍。在早期发育过程中，新生儿天生易发生兴奋性神经元活动，从而增加了癫痫发作的易感性。在这个亚人群中，癫痫持续状态的定义很差，缺乏共识定义。在这篇综述中，我们讨论了新生儿复发性癫痫的常见病因，以及目前在监测和治疗方面的趋势。最后，我们讨论了目前在动物和人类研究中的证据，表明新生儿癫痫发作可能对不成熟的大脑有害，导致不良的长期神经发育结果。
