Machado Giscard José Ribeiro, Dias Sheila Mônica Damásio, Bosco Alvaro Fancisco, Okamoto Tetuo, Bedran de Castro João César, Dornelles Rita Cássia Menegati
Department of Basic Sciences, Dental School of Araçatuba, UNESP-University Estadual Paulista, São Paulo, Brazil.
J Oral Maxillofac Surg. 2010 Nov;68(11):2675-81. doi: 10.1016/j.joms.2010.04.018. Epub 2010 Aug 19.
The purpose of this study was to evaluate the effects of nicotine and ovariectomy on alveolar bone regeneration after exodontias in rats.
For 30 days, sham ovariectomized (OVX)/NaCl, sham OVX/nicotine, OVX/NaCl, and OVX/nicotine animals were given 2 daily injections of saline or hemisulfate of nicotine. After this period, exodontic procedures were carried out and treatment continued up to the time of euthanasia on days 7 and 14 when the alveoli were removed for further analyses.
The data confirmed that nicotine significantly delays the alveolar regeneration process after dental extraction in rats and showed that the association of nicotine with ovariectomy exacerbates these results.
These results indicate that nicotine potentiated the effect of estrogen deficiency on bone regeneration induced by ovariectomy.
本研究旨在评估尼古丁和卵巢切除对大鼠拔牙后牙槽骨再生的影响。
对假卵巢切除（OVX）/生理盐水、假OVX/尼古丁、OVX/生理盐水和OVX/尼古丁的动物，连续30天每日注射两次生理盐水或尼古丁半硫酸盐。在此期间后，进行拔牙手术，并持续治疗至第7天和第14天安乐死时，取出牙槽进行进一步分析。
数据证实尼古丁显著延迟大鼠拔牙后的牙槽再生过程，并表明尼古丁与卵巢切除的联合加剧了这些结果。
这些结果表明尼古丁增强了雌激素缺乏对卵巢切除诱导的骨再生的影响。
