Ohta Nobuo, Fukase Shigeru, Suzuki Yusuke, Aoyagi Masaru
Department of Otolaryngology, Yamagata University School of Medicine, 2-2-2, Iida-nishi, Yamagata, Yamagata 990-9585, Japan.
Auris Nasus Larynx. 2011 Apr;38(2):240-3. doi: 10.1016/j.anl.2010.07.003. Epub 2010 Aug 19.
The aim of this paper was to evaluate the outcome and complications of the treatment of patients with salivary mucocele by intralesional injection therapy with OK-432.
We tried OK-432 therapy in 20 patients with salivary mucocele. We injected OK-432 solution into the lesion with a 27-gauge needle to prevent any leakage of the agent from the mucocele.
Disappearance of the lesion was observed in 16 of 20 patients. Marked reduction was observed in 4 of 20 patients. No local scarring or deformity of the lower lip occurred in any patients. As side effects, local discomfort at the injection site was observed in two of the patients, but such problems resolved within a few days. We performed this treatment on an outpatient basis without hospitalization.
Our results confirmed that OK-432 therapy is simple, easy, and relatively safe, and can be used as a substitute for surgery in the treatment of salivary mucocele.
本文旨在评估用OK-432病灶内注射疗法治疗唾液腺黏液囊肿患者的疗效及并发症。
我们对20例唾液腺黏液囊肿患者尝试了OK-432疗法。我们用27号针头将OK-432溶液注入病灶，以防止药物从黏液囊肿中漏出。
20例患者中有16例病灶消失。20例患者中有4例病灶明显缩小。所有患者均未出现下唇局部瘢痕或畸形。作为副作用，2例患者在注射部位出现局部不适，但此类问题在几天内得到解决。我们在门诊进行了此项治疗，无需住院。
我们的结果证实，OK-432疗法简单、易行且相对安全，可作为唾液腺黏液囊肿治疗中手术的替代方法。
