Kajimura N, Mizuki Y, Kai S, Suetsugi M, Sekimoto M, Fujii S, Yamada M, Yamadera H, Okuma T
Department of Neuropsychiatry, Yamaguchi University School of Medicine, Ube, Japan.
Methods Find Exp Clin Pharmacol. 1991 Mar;13(2):139-45.
The effects of 40 mg of indeloxazine hydrochloride, a cerebral metabolic enhancer, on sleep were investigated in 6 healthy male students. Polygraphic recordings were made for 8 consecutive nights on each subject. An inert placebo was given on the first 3 nights and on the 7th and 8th nights, and 40 mg of indeloxazine was administered on the 4th, 5th and 6th nights. Drug and placebo were administered orally at 21:30 h, and the recording of polysomnograms started at 22:00 h and ended at 8:00 h the next morning. The polysomnograms were evaluated by computerized automatic analysis using the interval histogram method. Indeloxazine prolonged both sleep latency and REM latency, and increased stage 1 sleep, but decreased stages 3, 4 and REM sleep. A significant increase of REM sleep was observed on the 7th and 8th recovery nights. No obvious changes were shown in the subjective assessments after administration of the drug. These results suggest that the effects of indeloxazine on sleep are similar to those of the tricyclic antidepressants. Furthermore, polysomnographic examinations might be useful in evaluating the pharmacological properties of cerebral metabolic enhancers.
在6名健康男学生中研究了40毫克盐酸茚达品（一种脑代谢增强剂）对睡眠的影响。对每个受试者连续8个晚上进行多导睡眠图记录。在前3个晚上以及第7和第8个晚上给予惰性安慰剂，在第4、5和6个晚上给予40毫克茚达品。药物和安慰剂于21:30口服给药，多导睡眠图记录于22:00开始，次日早上8:00结束。使用间隔直方图法通过计算机自动分析对多导睡眠图进行评估。茚达品延长了睡眠潜伏期和快速眼动潜伏期，增加了1期睡眠，但减少了3期、4期和快速眼动睡眠。在第7和第8个恢复晚上观察到快速眼动睡眠显著增加。给药后主观评估未显示明显变化。这些结果表明，茚达品对睡眠的影响与三环类抗抑郁药相似。此外，多导睡眠图检查可能有助于评估脑代谢增强剂的药理特性。
