Division of Protein Engineering, Cancer Institute, Japanese Foundation for Cancer Research, Koto, Tokyo 135-8550, Japan.
Curr Opin Biotechnol. 2010 Aug;21(4):412-25. doi: 10.1016/j.copbio.2010.07.008. Epub 2010 Aug 20.
Short amino acid sequences extracted from natural proteins or created using in vitro evolution systems are sometimes associated with particular biological functions. These peptides, called peptide motifs, can serve as functional units for the creation of various tools for nanobiotechnology. In particular, peptide motifs that have the ability to specifically recognize the surfaces of solid materials and to mineralize certain inorganic materials have been linking biological science to material science. Here, I review how these peptide motifs have been isolated from natural proteins or created using in vitro evolution systems, and how they have been used in the nanobiotechnology field.
从天然蛋白质中提取或使用体外进化系统创建的短氨基酸序列有时与特定的生物功能相关。这些肽,称为肽基序,可以作为创建各种纳米生物技术工具的功能单元。特别是,具有特异性识别固体材料表面和矿化某些无机材料能力的肽基序将生物科学与材料科学联系起来。在这里,我回顾了这些肽基序如何从天然蛋白质中分离或使用体外进化系统创建,以及它们如何在纳米生物技术领域中使用。