Departamento de Quimica/Instituto de Tecnologia Quimica UPV-CSIC, Universidad Politecnica de Valencia, Valencia, Spain.
J Photochem Photobiol B. 2010 Dec 2;101(3):295-303. doi: 10.1016/j.jphotobiol.2010.07.015. Epub 2010 Jul 30.
The presence of copper(II) in the micromolar range modulates the photodegradation rate of the fluoroquinolone Rufloxacin (RFX), both under air and in nitrogen saturated aqueous solution. The photodegradation rate of RFX under aerobic conditions decreases in the presence of metal ions, and no change in the nature of the photoproducts is observed. In anaerobic media, RFX photodegradation rate increases with increasing copper(II) concentration and the photoproducts distribution changes. Copper(II) inhibits formation of type II products of 2'-deoxyguanosine diagnostic of photosensitization mediated by singlet oxygen. The overall results provide a clear example demonstrating how a bio-compatible trace element influences efficiently not only the bioavailability of a drug but also its molecular mechanism of photodegradation and photosensitization.
在微摩尔范围内存在的铜（II）可调节氟喹诺酮类药物（RFX）的光降解速率，无论是在空气还是在氮气饱和水溶液中都是如此。在有氧条件下，RFX 的光降解速率在金属离子存在的情况下降低，并且没有观察到光产物的性质发生变化。在厌氧介质中，随着铜（II）浓度的增加，RFX 的光降解速率增加，并且光产物的分布发生变化。铜（II）抑制 2'-脱氧鸟苷的 II 型产物的形成，该产物是由单线态氧介导的光致敏化的诊断性产物。总的结果提供了一个明确的例子，表明生物相容性微量元素如何不仅有效地影响药物的生物利用度，而且还影响其光降解和光致敏化的分子机制。
