Droupy S
Service d'Urologie-Andrologie, CHU Carémeau, place du Pr-Robert-Debré, 30029 Nîmes cedex 09, France.
Cancer Radiother. 2010 Oct;14(6-7):504-9. doi: 10.1016/j.canrad.2010.07.223. Epub 2010 Aug 21.
Sexual dysfunctions are a quality of life main concern following prostate cancer treatment. After both radiotherapy and brachytherapy, sexual function declines progressively, the onset of occurrence of erectile dysfunction being 12-18 months after both treatments. The pathophysiological pathways by which radiotherapy and brachytherapy cause erectile dysfunction are multifactorial, as patient comorbidities, arterial damage, exposure of neurovascular bundle to high levels of radiation, and radiation dose received by the corpora cavernosa at the crurae of the penis may be important in the aetiology of erectile dysfunction. Diagnosis and treatment of postradiation sexual dysfunctions must integrate pretherapeutic evaluation and information to provide to the patient and his partner a multidisciplinary sexual medicine management.
性功能障碍是前列腺癌治疗后生活质量的主要关注点。放疗和近距离放射治疗后,性功能都会逐渐下降,两种治疗后勃起功能障碍的发病时间为12 - 18个月。放疗和近距离放射治疗导致勃起功能障碍的病理生理途径是多因素的,因为患者的合并症、动脉损伤、神经血管束暴露于高水平辐射以及阴茎脚海绵体接受的辐射剂量可能在勃起功能障碍的病因中起重要作用。放疗后性功能障碍的诊断和治疗必须整合治疗前评估以及向患者及其伴侣提供的信息,以提供多学科的性医学管理。