Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Menoufiya University, Sadat City Branch, Egypt.
Food Chem Toxicol. 2010 Nov;48(11):3153-8. doi: 10.1016/j.fct.2010.08.011. Epub 2010 Aug 20.
Exposure of male (55.1 mg/kg b.wt. orally for 60 days) and/or pregnant female Wistar rats (55.1 mg/kg b.wt. orally at days 6-15 of gestation), to the insecticide cypermethrin (CYP); resulted in the development of a lot of external morphological deformities and visceral malformations in their offspring pubs, which signify the potential of such insecticide to induce reproductive toxicity and teratogenesis. Data cleared that CYP treatment induced significant increase in the percentages of post-implantation deaths, dwarf foeti and subcutaneous oedema beside significant decrease in percentages of live borne foeti and uterine implants. CYP also caused many visceral malformations among different treated groups including nasal, ophthalmic, cerebral, pulmonary, cardiac and renal malformations. Concomitant oral administration of garlic extract or vitamin C (5 days/week) to treated fathers and/or pregnant mothers with CYP provided significant reduction in the percentage of the foetal malformations induced by the insecticide, when compared with the control. The current study proves that garlic and ascorbic acid dampen the reproductive toxicity and/or teratogenicity of cypermethrin toxicity in rats; therefore might prove to be effective dietary supplements in developing countries where pesticide pollution is high.
雄性（55.1mg/kg bw 口服 60 天）和/或怀孕雌性 Wistar 大鼠（55.1mg/kg bw 在妊娠第 6-15 天口服）暴露于杀虫剂氯菊酯（CYP）中；导致其后代出现大量外部形态畸形和内脏畸形，表明这种杀虫剂具有潜在的生殖毒性和致畸性。数据表明，CYP 处理会导致着床后死亡、矮胎和皮下水肿的百分比显著增加，而活胎和子宫植入物的百分比显著降低。CYP 还会导致不同处理组出现许多内脏畸形，包括鼻、眼、脑、肺、心脏和肾脏畸形。与对照组相比，同时给予大蒜提取物或维生素 C（每周 5 天）给用 CYP 处理的父亲和/或怀孕母亲，可显著降低杀虫剂引起的胎儿畸形百分比。本研究证明，大蒜和抗坏血酸可减轻氯菊酯毒性对大鼠的生殖毒性和/或致畸性；因此，在农药污染较高的发展中国家，可能被证明是有效的膳食补充剂。
