扁桃体切除术对复发性扁桃体炎患者呼出气一氧化氮（NO）水平的影响。
Effect of tonsillectomy on the level of exhaled nitric oxide (NO) in patients with recurrent tonsillitis.
机构信息
Chair and Clinical Department of Internal Diseases, Allergology and Clinical Immunology, Medical University of Silesia, Katowice, Poland.
出版信息
Respir Med. 2010 Nov;104(11):1757-9. doi: 10.1016/j.rmed.2010.07.024. Epub 2010 Aug 21.
BACKGROUND
Increased expression of inducible nitric oxide synthase in inflamed tonsils has been reported. Our preliminary observation was the first to demonstrate that increased exhaled NO level may occur in patients with tonsillitis.
OBJECTIVE
To extend the observation scope, the same group of patients was examined for NO exhaled after tonsillectomy.
MATERIALS AND METHODS
Exhaled oral NO level was measured with Niox Mino(®) analyzer, six-seven months after tonsillectomy in 27 non-atopic patients who suffered from recurrent tonsillitis and in 35 healthy non-atopic subjects.
RESULTS
After tonsillectomy, exhaled NO levels were significantly reduced as compared to the preoperative period values and did not differ significantly from those of the healthy subjects.
CONCLUSIONS
The results support a finding of the elevated exhaled NO consequent to NO production in chronically inflamed tonsils, but whether NO plays any role in the pathogenesis of tonsillitis or is merely a by-product of another process, needs to be determined.
背景
已有研究报告称，在炎症性扁桃体中诱导型一氧化氮合酶的表达增加。我们的初步观察结果首次表明，扁桃体炎患者可能会出现呼出的一氧化氮水平升高。
目的
为了扩大观察范围，对同一组接受扁桃体切除术的患者进行了检测。
材料和方法
在扁桃体切除术后 6-7 个月，使用 Niox Mino（®）分析仪对 27 例非变应性复发性扁桃体炎患者和 35 例健康非变应性对照者的口腔呼出气一氧化氮水平进行了测量。
结果
与术前相比，扁桃体切除术后呼出气一氧化氮水平显著降低，且与健康对照组无显著差异。
结论
这些结果支持慢性炎症扁桃体中由于一氧化氮生成而导致呼出气一氧化氮升高的发现，但一氧化氮是否在扁桃体炎的发病机制中起作用，或者仅仅是另一种过程的副产物，尚需确定。
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