miR-103/7 和泛酸激酶宿主基因在小鼠中的表达失调。
Discordant expression of miR-103/7 and pantothenate kinase host genes in mouse.
机构信息
Molecular and Medical Genetics, Oregon Health & Science University, Portland OR, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA.
出版信息
Mol Genet Metab. 2010 Oct-Nov;101(2-3):292-5. doi: 10.1016/j.ymgme.2010.07.016. Epub 2010 Aug 4.
Abstract
miR-103 and miR-107, microRNAs hosted by pantothenate kinase genes, are proposed to regulate cellular lipid metabolism. microRNA-mediated regulation is complex, potentially affecting expression of the host gene, related enzymes within the same pathway, or apparently distinct targets. Using qRT-PCR, we demonstrate that miR-103 and miR-107 expression does not correlate with expression of host pantothenate kinase genes in mouse tissues. The miR-103/7 family thus provides an intriguing model for dissecting microRNA transcription, processing and coordinated function within host genes.
摘要
miR-103 和 miR-107 是由泛酸激酶基因编码的 microRNA，据推测它们可以调节细胞内的脂质代谢。microRNA 的调节作用非常复杂，可能会影响宿主基因的表达、同一通路内的相关酶，或者明显不同的靶标。我们通过 qRT-PCR 实验表明，miR-103 和 miR-107 的表达与小鼠组织中宿主泛酸激酶基因的表达不相关。miR-103/7 家族为解析 microRNA 在宿主基因中的转录、加工和协调功能提供了一个有趣的模型。
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