Department of Oral and Maxillofacial Surgery, University of Nis School of Medicine and Stomatology, Serbia.
Dentomaxillofac Radiol. 2010 Sep;39(6):383-8. doi: 10.1259/dmfr/16059055.
Non-Hodgkin's lymphoma has the propensity to affect non-lymphoid tissue including oral tissue. Primary non-Hodgkin's lymphoma of the mandible mistreated as chronic periodontitis with diffuse enlargement of the mandibular canal and ice-cold numbness is very rarely described in English medical literature. A 57-year-old patient presented with a painful swelling on the left side of the mandible with a clinically chronic periodontitis associated with ice-cold numbness. A panoramic radiograph showed a diffuse uniform enlargement of the mandibular canal. Histological examination showed that the lesion was a primary intraosseous non-Hodgkin's lymphoma of the mandible. Immunohistochemical examination showed a positive reaction for CD20+, Ki-67+. Seven months after chemotherapy the patient was observed for possible life-threatening propagation of the disease. In conclusion, primary (extra-nodal) non-Hodgkin's lymphoma of the mandible usually clinically presents with bone swelling, teeth mobility and neurological disturbance. Radiographic features presenting as diffuse enlargement of the mandibular canal could be considered as non-Hodgkin's lymphoma.
非霍奇金淋巴瘤有倾向于影响非淋巴组织，包括口腔组织。下颌骨原发性非霍奇金淋巴瘤误诊为慢性牙周炎，伴有下颌管弥漫性扩大和冰冷麻木，在英文医学文献中很少有描述。一名 57 岁患者因左侧下颌骨疼痛肿胀就诊，伴有临床慢性牙周炎和冰冷麻木。全景片显示下颌管弥漫均匀扩大。组织学检查显示病变为下颌骨原发性骨内非霍奇金淋巴瘤。免疫组织化学检查显示 CD20+、Ki-67+阳性反应。化疗后 7 个月，对患者进行了观察，以发现可能危及生命的疾病进展。总之，下颌骨原发性（结外）非霍奇金淋巴瘤通常临床上表现为骨肿胀、牙齿松动和神经功能障碍。表现为下颌管弥漫性扩大的影像学特征可被认为是非霍奇金淋巴瘤。
