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The bell-shaped curve for peroxynitrite-mediated oxidation and nitration of NO/O2-* is alive and well.过氧亚硝酸盐介导的一氧化氮/超氧阴离子氧化和硝化的钟形曲线依然存在且状态良好。
J Biol Chem. 2010 Aug 27;285(35):le15. doi: 10.1074/jbc.L110.110080.
2
Peroxynitrite is the major species formed from different flux ratios of co-generated nitric oxide and superoxide: direct reaction with boronate-based fluorescent probe.过氧亚硝酸盐是由不同比例生成的一氧化氮和超氧化物共同作用形成的主要物种：与硼酸盐荧光探针的直接反应。
J Biol Chem. 2010 May 7;285(19):14210-6. doi: 10.1074/jbc.M110.110080. Epub 2010 Mar 1.
3
Detection and differentiation between peroxynitrite and hydroperoxides using mitochondria-targeted arylboronic acid.使用线粒体靶向芳基硼酸检测过氧亚硝酸盐和氢过氧化物并进行区分。
Methods Mol Biol. 2015;1264:171-81. doi: 10.1007/978-1-4939-2257-4_16.
4
Peroxynitrite, a stealthy biological oxidant.过氧亚硝酸盐，一种隐秘的生物氧化剂。
J Biol Chem. 2013 Sep 13;288(37):26464-72. doi: 10.1074/jbc.R113.472936. Epub 2013 Jul 16.
5
Boronate probes as diagnostic tools for real time monitoring of peroxynitrite and hydroperoxides.硼酸探针作为实时监测过氧亚硝酸盐和过氧化物的诊断工具。
Chem Res Toxicol. 2012 Sep 17;25(9):1793-9. doi: 10.1021/tx300164j. Epub 2012 Jun 25.
6
Direct oxidation of boronates by peroxynitrite: mechanism and implications in fluorescence imaging of peroxynitrite.过氧亚硝酸盐直接氧化硼酸酯：机制及在过氧亚硝酸盐荧光成像中的意义。
Free Radic Biol Med. 2009 Nov 15;47(10):1401-7. doi: 10.1016/j.freeradbiomed.2009.08.006. Epub 2009 Aug 14.
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The labile iron pool attenuates peroxynitrite-dependent damage and can no longer be considered solely a pro-oxidative cellular iron source.不稳定铁池可减轻过氧亚硝酸盐依赖性损伤，不能再被单纯视为促氧化细胞铁源。
J Biol Chem. 2018 Jun 1;293(22):8530-8542. doi: 10.1074/jbc.RA117.000883. Epub 2018 Apr 16.
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Peroxynitrite generation from a NO-releasing nitrobenzene derivative in response to photoirradiation.硝普盐衍生物在光辐射下生成过氧亚硝基。
Chem Commun (Camb). 2011 Jun 14;47(22):6449-51. doi: 10.1039/c1cc11681a. Epub 2011 May 6.
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Identification of Peroxynitrite by Profiling Oxidation and Nitration Products from Mitochondria-Targeted Arylboronic Acid.通过分析靶向线粒体的芳基硼酸的氧化和硝化产物来鉴定过氧亚硝酸盐。
Methods Mol Biol. 2021;2275:315-327. doi: 10.1007/978-1-0716-1262-0_20.
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Nitroxidative chemistry interferes with fluorescent probe chemistry: implications for nitric oxide detection using 2,3-diaminonaphthalene.氮氧自由基化学会干扰荧光探针化学：对使用 2,3-二氨基萘检测一氧化氮的影响。
Biochem Biophys Res Commun. 2014 Aug 22;451(2):196-201. doi: 10.1016/j.bbrc.2014.07.097. Epub 2014 Jul 28.

引用本文的文献

1
Vascular aging: chronic oxidative stress and impairment of redox signaling-consequences for vascular homeostasis and disease.血管老化：慢性氧化应激和氧化还原信号转导损伤——对血管稳态和疾病的影响。
Ann Med. 2013 Feb;45(1):17-36. doi: 10.3109/07853890.2011.645498. Epub 2012 Mar 1.
2
Peroxynitrite mediates active site tyrosine nitration in manganese superoxide dismutase. Evidence of a role for the carbonate radical anion.过氧亚硝酸盐介导锰超氧化物歧化酶活性部位酪氨酸硝化。碳酸盐自由基阴离子作用的证据。
J Am Chem Soc. 2010 Dec 8;132(48):17174-85. doi: 10.1021/ja105684w. Epub 2010 Nov 16.

本文引用的文献

1
Peroxynitrite is the major species formed from different flux ratios of co-generated nitric oxide and superoxide: direct reaction with boronate-based fluorescent probe.过氧亚硝酸盐是由不同比例生成的一氧化氮和超氧化物共同作用形成的主要物种：与硼酸盐荧光探针的直接反应。
J Biol Chem. 2010 May 7;285(19):14210-6. doi: 10.1074/jbc.M110.110080. Epub 2010 Mar 1.
2
Reaction of superoxide and nitric oxide with peroxynitrite. Implications for peroxynitrite-mediated oxidation reactions in vivo.超氧化物和一氧化氮与过氧亚硝酸根的反应。对体内过氧亚硝酸根介导的氧化反应的影响。
J Biol Chem. 2001 Aug 3;276(31):28799-805. doi: 10.1074/jbc.M102341200. Epub 2001 May 23.
3
The oxidative and nitrosative chemistry of the nitric oxide/superoxide reaction in the presence of bicarbonate.在碳酸氢盐存在下一氧化氮/超氧化物反应的氧化和亚硝化化学。
Arch Biochem Biophys. 1999 May 1;365(1):92-100. doi: 10.1006/abbi.1999.1143.
4
Lack of tyrosine nitration by peroxynitrite generated at physiological pH.在生理pH值下由过氧亚硝酸盐生成的酪氨酸硝化作用缺失。
J Biol Chem. 1998 Oct 16;273(42):27280-5. doi: 10.1074/jbc.273.42.27280.

The bell-shaped curve for peroxynitrite-mediated oxidation and nitration of NO/O2-* is alive and well.

作者信息

Jourd'heuil David, Lancaster Jack R, Fukuto Jon, Roberts David D, Miranda Katrina M, Mayer Bernd, Grisham Mathew B, Wink David A

机构信息

Center for Cardiovascular Sciences, Albany Medical College, Albany, New York.

Center for Free Radical Biology and Departments of Anesthesiology, Physiology & Biophysics, and Environmental Health Sciences, University of Alabama Birmingham, Birmingham, Alabama.

出版信息

J Biol Chem. 2010 Aug 27;285(35):le15. doi: 10.1074/jbc.L110.110080.

DOI:10.1074/jbc.L110.110080
PMID:20729216
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2930750/
Abstract
摘要