预防胜于治疗：治疗性癌症疫苗在预防环境中进行临床试验的理由。
Prevention is better than cure: the case for clinical trials of therapeutic cancer vaccines in the prophylactic setting.
作者信息
Gray Andrew, Yan Lisa, Kast W Martin
机构信息
Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA.
出版信息
Mol Interv. 2010 Aug;10(4):197-203. doi: 10.1124/mi.10.4.2.
Abstract
Tumor cells frequently express antigens that allow them to be specifically targeted and destroyed by the immune system. Many tumor immunotherapy clinical trials have been conducted, directed at several types of cancer using myriad antigens and multiple immunization strategies. Despite this, only one therapeutic cancer vaccine, sipuleucel-T, has been approved. A groundbreaking study by Jaini et al. recently demonstrated that prophylactic immunization against a breast cancer associated antigen can prevent tumor development, and is far more effective than therapeutic vaccination. This study highlights the urgent need to rethink the clinical testing of tumor immunotherapies; it is time to consider clinical trials of cancer vaccines in the prophylactic setting.
摘要
肿瘤细胞经常表达一些抗原，这些抗原能使它们被免疫系统特异性地靶向并摧毁。针对多种癌症类型，利用无数抗原和多种免疫策略，已经开展了许多肿瘤免疫疗法的临床试验。尽管如此，目前仅有一种治疗性癌症疫苗——西妥昔单抗已获批准。Jaini等人最近的一项开创性研究表明，针对一种乳腺癌相关抗原进行预防性免疫可以预防肿瘤的发生，而且比治疗性疫苗接种更为有效。这项研究凸显了迫切需要重新思考肿瘤免疫疗法的临床试验；现在是时候考虑在预防性环境中开展癌症疫苗的临床试验了。
相似文献
1
Prevention is better than cure: the case for clinical trials of therapeutic cancer vaccines in the prophylactic setting.预防胜于治疗：治疗性癌症疫苗在预防环境中进行临床试验的理由。
Mol Interv. 2010 Aug;10(4):197-203. doi: 10.1124/mi.10.4.2.
2
Review: cancer immunotherapy by exosome-based vaccines.综述：基于外泌体的疫苗用于癌症免疫治疗
Cancer Biother Radiopharm. 2007 Oct;22(5):692-703. doi: 10.1089/cbr.2007.368-R.
3
Therapeutic cancer vaccines in the treatment of non-small-cell lung cancer.治疗性癌症疫苗在非小细胞肺癌治疗中的应用。
Expert Rev Vaccines. 2013 Mar;12(3):263-70. doi: 10.1586/erv.13.14.
4
Cancer vaccines 2000.2000年癌症疫苗
Immunol Lett. 2000 Sep 15;74(1):1-3. doi: 10.1016/s0165-2478(00)00242-x.
5
Cancer vaccines and immunotherapy.癌症疫苗与免疫疗法。
Hum Vaccin. 2009 Oct;5(10):666. doi: 10.4161/hv.5.10.9132. Epub 2009 Oct 1.
6
Clinical trials targeting lung cancer with active immunotherapy: the scope of vaccines.以主动免疫疗法治疗肺癌的临床试验：疫苗的应用范围
Expert Rev Anticancer Ther. 2005 Aug;5(4):635-44. doi: 10.1586/14737140.5.4.635.
7
Exploiting dendritic cells for active immunotherapy of cancer and chronic infections.利用树突状细胞进行癌症和慢性感染的主动免疫治疗。
Mol Biotechnol. 2007 Jun;36(2):131-41. doi: 10.1007/s12033-007-0020-6.
8
Cancer vaccines inducing antibody production: more pros than cons.癌症疫苗诱导抗体产生：利大于弊。
Expert Rev Vaccines. 2011 Sep;10(9):1281-9. doi: 10.1586/erv.11.105.
9
Tumor immunogenicity and responsiveness to cancer vaccine therapy: the state of the art.肿瘤免疫原性和对癌症疫苗治疗的反应性：最新进展。
Semin Immunol. 2010 Jun;22(3):105-12. doi: 10.1016/j.smim.2010.02.001. Epub 2010 Mar 11.
10
Priming anticancer active specific immunotherapy with dendritic cells.用树突状细胞启动抗癌活性特异性免疫疗法。
Curr Opin Investig Drugs. 2005 Jun;6(6):576-81.
引用本文的文献
1
Modulation of the tumor microenvironment and mechanism of immunotherapy-based drug resistance in breast cancer.乳腺癌中肿瘤微环境的调节和基于免疫治疗的耐药机制。
Mol Cancer. 2024 May 7;23(1):92. doi: 10.1186/s12943-024-01990-4.
2
Immunotherapy in breast cancer: an overview of current strategies and perspectives.乳腺癌免疫治疗：当前策略与前景综述
NPJ Breast Cancer. 2023 Feb 13;9(1):7. doi: 10.1038/s41523-023-00508-3.
3
Vaccines for cancer prevention: a practical and feasible approach to the cancer epidemic.癌症预防疫苗：应对癌症流行的实用可行方法。
Cancer Immunol Res. 2014 Aug;2(8):708-13. doi: 10.1158/2326-6066.CIR-14-0110.
4
Sialyl-tn in cancer: (how) did we miss the target?唾液酸化-Tn 在癌症中的作用：（我们）为何错失了靶点？
Biomolecules. 2012 Oct 11;2(4):435-66. doi: 10.3390/biom2040435.
5
Immunotherapy in prostate cancer: emerging strategies against a formidable foe.前列腺癌的免疫疗法：对抗强敌的新兴策略。
Vaccine. 2011 Sep 2;29(38):6485-97. doi: 10.1016/j.vaccine.2011.06.088. Epub 2011 Jul 7.
本文引用的文献
1
An autoimmune-mediated strategy for prophylactic breast cancer vaccination.一种用于预防性乳腺癌疫苗接种的自身免疫介导策略。
Nat Med. 2010 Jul;16(7):799-803. doi: 10.1038/nm.2161. Epub 2010 May 30.
2
Overall survival analysis of a phase II randomized controlled trial of a Poxviral-based PSA-targeted immunotherapy in metastatic castration-resistant prostate cancer.基于痘病毒的 PSA 靶向免疫治疗转移性去势抵抗性前列腺癌的 II 期随机对照试验的总生存分析。
J Clin Oncol. 2010 Mar 1;28(7):1099-105. doi: 10.1200/JCO.2009.25.0597. Epub 2010 Jan 25.
3
Prostate cancer immunotherapy yields superior long-term survival in TRAMP mice when administered at an early stage of carcinogenesis prior to the establishment of tumor-associated immunosuppression at later stages.在肿瘤相关免疫抑制在后期建立之前，在致癌作用的早期对 TRAMP 小鼠进行前列腺癌免疫治疗，可显著提高长期存活率。
Vaccine. 2009 Dec 30;27 Suppl 6(Suppl 6):G52-9. doi: 10.1016/j.vaccine.2009.09.106.
4
Integrated data from 2 randomized, double-blind, placebo-controlled, phase 3 trials of active cellular immunotherapy with sipuleucel-T in advanced prostate cancer.来自两项关于用西妥昔单抗进行活性细胞免疫疗法治疗晚期前列腺癌的3期随机、双盲、安慰剂对照试验的综合数据。
Cancer. 2009 Aug 15;115(16):3670-9. doi: 10.1002/cncr.24429.
5
Chemoprevention of prostate cancer.前列腺癌的化学预防
J Urol. 2009 Aug;182(2):499-507; discussion 508. doi: 10.1016/j.juro.2009.04.015. Epub 2009 Jun 13.
6
A paradigm shift in therapeutic vaccination of cancer patients: the need to apply therapeutic vaccination strategies in the preventive setting.癌症患者治疗性疫苗接种的范式转变：在预防环境中应用治疗性疫苗接种策略的必要性。
Immunol Rev. 2008 Apr;222:316-27. doi: 10.1111/j.1600-065X.2008.00605.x.
7
Prostate stem cell antigen vaccination induces a long-term protective immune response against prostate cancer in the absence of autoimmunity.前列腺干细胞抗原疫苗接种在无自身免疫的情况下可诱导针对前列腺癌的长期保护性免疫反应。
Cancer Res. 2008 Feb 1;68(3):861-9. doi: 10.1158/0008-5472.CAN-07-0445.
8
American Cancer Society guidelines for breast screening with MRI as an adjunct to mammography.美国癌症协会关于以MRI作为乳房X线摄影辅助手段进行乳房筛查的指南。
CA Cancer J Clin. 2007 Mar-Apr;57(2):75-89. doi: 10.3322/canjclin.57.2.75.
9
In vivo effects of vaccination with six-transmembrane epithelial antigen of the prostate: a candidate antigen for treating prostate cancer.前列腺六次跨膜上皮抗原疫苗接种的体内效应：一种治疗前列腺癌的候选抗原。
Cancer Res. 2007 Feb 1;67(3):1344-51. doi: 10.1158/0008-5472.CAN-06-2996.
10
Immune resistance orchestrated by the tumor microenvironment.由肿瘤微环境精心策划的免疫抵抗。
Immunol Rev. 2006 Oct;213:131-45. doi: 10.1111/j.1600-065X.2006.00442.x.
Zotero 插件