Eastern Virginia Medical School, Norfolk, Virginia, USA.
Adv Skin Wound Care. 2010 Sep;23(9):406-13. doi: 10.1097/01.ASW.0000383213.95911.bc.
Antibiotic resistance is increasing among organisms that commonly cause wound infections. Therefore, it becomes increasingly desirable to prevent wound infections as systemic antibiotic treatment of established wound infections becomes more difficult, more expensive, and potentially more toxic. The ability to incorporate antimicrobial compounds into modern wound dressings provides an opportunity to prevent wound infections without the risk of systemic toxicity, thus diminishing morbidity, mortality, and cost to the healthcare system.
In these studies, the authors tested 16 antimicrobial agents in a unique composite wound dressing (TheraGauze; Soluble Systems, LLC, Newport News, Virginia) against clinical methicillin-resistant Staphylococcus aureus isolates and Gram-negative organisms commonly associated with wound infections and antibiotic resistance. Disk diffusion susceptibility testing is used to quantify antimicrobial activity.
Broad-spectrum antimicrobial activity was found for the following agents in the composite wound dressing: hydrogen peroxide, tobramycin, chlorhexidine digluconate, chlorhexidine gluconate, levofloxacin, and silver.
These studies suggest that potent local antibacterial activity can be achieved with several antimicrobials in this wound dressing.
在通常引起伤口感染的生物体中，抗生素耐药性正在增加。因此，预防伤口感染变得越来越重要，因为治疗已确立的伤口感染的全身性抗生素治疗变得更加困难、更加昂贵并且潜在地更具毒性。将抗菌化合物纳入现代伤口敷料的能力为预防伤口感染提供了机会，而不会有全身毒性的风险，从而降低了发病率、死亡率和医疗保健系统的成本。
在这些研究中，作者针对临床耐甲氧西林金黄色葡萄球菌分离株和与伤口感染和抗生素耐药性相关的常见革兰氏阴性菌，在一种独特的复合伤口敷料（TheraGauze；Soluble Systems，LLC，Newport News，VA）中测试了 16 种抗菌剂。使用圆盘扩散药敏试验来量化抗菌活性。
在复合伤口敷料中发现了以下几种药物的广谱抗菌活性：过氧化氢、妥布霉素、洗必泰葡萄糖酸、葡萄糖酸氯己定、左氧氟沙星和银。
这些研究表明，这种伤口敷料中的几种抗菌剂可以实现有效的局部抗菌活性。
