Cristea Hohotă Alina-Georgiana, Lisă Elena-Lăcrămioara, Iacob Ciobotaru Simona, Dragostin Ionut, Ștefan Claudia Simona, Fulga Iuliu, Anghel Ștefan Andra Monica, Dragan Maria, Morariu Ionela Daniela, Dragostin Oana-Maria
Research Centre in the Medical-Pharmaceutical Field, Faculty of Medicine and Pharmacy, "Dunarea de Jos" University, 800201 Galati, Romania.
Department of Pharmaceutical Sciences II, Faculty of Pharmacy, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Pharmaceuticals (Basel). 2025 May 30;18(6):825. doi: 10.3390/ph18060825.
Wound healing is a complex, tightly regulated process essential for maintaining skin barrier function. Chronic wounds, often complicated by biofilm-forming bacteria and elevated oxidative stress, pose significant challenges in clinical management. The rise of antibiotic-resistant bacteria has further exacerbated the problem, limiting therapeutic options and complicating wound treatment. Traditional wound care approaches frequently fail to provide real-time accurate insights into wound status, leading to delayed or suboptimal treatments. Recent advancements in modern and smart wound dressings, which integrate various biosensors, different new drug delivery systems, and wireless communication technology, offers promising solutions for monitoring wound progression over time. These innovations enable early detection of adverse events such as bacterial infections and inflammation, facilitating more effective, on-demand treatment. This review highlights the current state of antibiotic-embedded wound dressings, discusses their limitations, and explores the potential of next-generation wound dressings incorporating microelectronic sensors for real-time monitoring and adaptive therapeutic responses to support healing and combat antimicrobial resistance.
伤口愈合是一个复杂且受到严格调控的过程，对于维持皮肤屏障功能至关重要。慢性伤口常常因形成生物膜的细菌和氧化应激升高而复杂化，在临床管理中构成重大挑战。抗生素耐药菌的出现进一步加剧了这一问题，限制了治疗选择并使伤口治疗变得复杂。传统的伤口护理方法常常无法提供关于伤口状态的实时准确见解，导致治疗延迟或不理想。现代智能伤口敷料的最新进展，集成了各种生物传感器、不同的新型药物递送系统和无线通信技术，为长期监测伤口进展提供了有前景的解决方案。这些创新能够早期检测出诸如细菌感染和炎症等不良事件，促进更有效、按需的治疗。本综述强调了含抗生素伤口敷料的当前状态，讨论了它们的局限性，并探索了结合微电子传感器以进行实时监测和适应性治疗反应的下一代伤口敷料在支持愈合和对抗抗菌耐药性方面的潜力。
