Kasza Jason, Espinel Francisco, Khambaty Fatima, Bashir Showkat, Brody Fred
Department of Surgery, The George Washington University Hospital, Washington, DC 20037, USA.
Surg Laparosc Endosc Percutan Tech. 2010 Aug;20(4):295-7. doi: 10.1097/SLE.0b013e3181e360d0.
Metastatic melanoma remains a disease associated with poor outcomes. Traditionally, surgical intervention plays a minimal role in its treatment. However, more recent studies document that complete surgical resection of distant metastases is associated with 5-year survival rates of 15% to 30%. These rates are greater than that reported for single-agent or combination chemotherapy, biologic agents or immunotherapy. This case report outlines a unique presentation of stage IV melanoma within the gastrointestinal tract located in 2 different organs. On the basis of the patient's clinical findings, laparoscopic surgery was performed for palliation of intestinal obstruction and bleeding. This approach resulted in less postoperative pain, earlier mobilization, and a faster return to daily activities. To our knowledge, this case details the only known account that uses a laparoscopic approach to palliate stage IV melanoma at 2 synchronous sites; the stomach and small bowel. The literature regarding the treatment of metastatic melanoma is also briefly reviewed.
转移性黑色素瘤仍然是一种预后较差的疾病。传统上,手术干预在其治疗中作用极小。然而,最近的研究表明,远处转移灶的完整手术切除与15%至30%的5年生存率相关。这些生存率高于单药或联合化疗、生物制剂或免疫治疗所报告的生存率。本病例报告概述了发生在胃肠道两个不同器官的IV期黑色素瘤的独特表现。根据患者的临床症状,进行了腹腔镜手术以缓解肠梗阻和出血。这种方法术后疼痛较轻,能更早活动,并能更快恢复日常活动。据我们所知,本病例详细介绍了唯一已知的采用腹腔镜方法缓解胃和小肠两个同步部位IV期黑色素瘤症状的病例。本文还简要回顾了有关转移性黑色素瘤治疗的文献。