一种使用全身性药物治疗自身免疫性大疱性疾病的实用方法。
A practical approach to treating autoimmune bullous disorders with systemic medications.
作者信息
Han Anne
机构信息
Dr. Han is Clinical Dermatopharmacology Fellow, Department of Dermatology, Mt. Sinai Medical Center, New York, New York.
出版信息
J Clin Aesthet Dermatol. 2009 May;2(5):19-28.
The bullous diseases comprise a heterogeneous group of skin disorders with distinct clinical and histological findings. They are characterized histologically by clefts at varying depths in the skin and are pathologically caused either by congenital defects or autoantibodies. Autoimmune bullous disorders are chronic conditions with significant morbidity and mortality in untreated patients. With the advent of immunosuppressive medications, mortality from these diseases has decreased significantly. However, complications from therapy itself are common causes of morbidity in these patients. Therefore, treatment of autoimmune bullous diseases is a challenge, as patients must remain on chronic medications with side effects that limit their use. This article aims to provide a practical approach to understanding the available medications for the treatment of autoimmune bullous diseases.
大疱性疾病是一组具有不同临床和组织学表现的异质性皮肤疾病。它们在组织学上的特征是皮肤不同深度出现裂隙，在病理上是由先天性缺陷或自身抗体引起的。自身免疫性大疱性疾病是慢性疾病，未经治疗的患者有显著的发病率和死亡率。随着免疫抑制药物的出现，这些疾病的死亡率已显著下降。然而，治疗本身的并发症是这些患者发病的常见原因。因此，自身免疫性大疱性疾病的治疗是一项挑战，因为患者必须长期服用有副作用的药物，这限制了药物的使用。本文旨在提供一种实用的方法来了解治疗自身免疫性大疱性疾病的可用药物。
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