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妊娠相关性自身免疫性大疱性疾病:临床和流行病学特征及治疗方法。

Autoimmune bullous diseases in pregnancy: clinical and epidemiological characteristics and therapeutic approach.

机构信息

Department of Dermatology, Faculty of Medicine, Universidade de São Paulo, São Paulo, SP, Brazil.

Department of Dermatology, Faculty of Medicine, Universidade de São Paulo, São Paulo, SP, Brazil.

出版信息

An Bras Dermatol. 2021 Sep-Oct;96(5):581-590. doi: 10.1016/j.abd.2020.10.007. Epub 2021 Jul 23.

Abstract

Autoimmune bullous dermatoses are a heterogeneous group of diseases with autoantibodies against structural skin proteins. Although the occurrence of autoimmune bullous dermatoses during pregnancy is low, this topic deserves attention, since the immunological and hormonal alterations that occur during this period can produce alterations during the expected course of these dermatoses. The authors review the several aspects of autoimmune bullous dermatoses that affect pregnant women, including the therapeutic approach during pregnancy and breastfeeding. Gestational pemphigoid, a pregnancy-specific bullous disease, was not studied in this review.

摘要

自身免疫性大疱性皮肤病是一组具有针对结构性皮肤蛋白自身抗体的异质性疾病。虽然妊娠期间自身免疫性大疱性皮肤病的发生率较低,但这一主题值得关注,因为在此期间发生的免疫和激素变化可能会导致这些皮肤病的预期病程发生变化。作者回顾了影响孕妇的几种自身免疫性大疱性皮肤病的方面,包括妊娠期间和哺乳期的治疗方法。本文未研究妊娠特发性大疱性疾病——妊娠疱疹。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ccc/8441454/fd88b08fd431/gr1.jpg

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