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评估接受冠状动脉旁路移植术患者的 EuroSCORE 风险评分模型:需谨慎。

Evaluation of the EuroSCORE risk scoring model for patients undergoing coronary artery bypass graft surgery: a word of caution.

机构信息

Department of Cardiothoracic Surgery, Catharina Hospital, Eindhoven, the Netherlands.

出版信息

Neth Heart J. 2010 Aug;18(7-8):355-9. doi: 10.1007/BF03091791.

Abstract

Background. Risk-adjusted mortality rates are used to compare quality of care of different hospitals. We evaluated the EuroSCORE (European System for Cardiac Operative Risk Evaluation) in patients undergoing isolated coronary artery bypass grafting (CABG).Patients and method. Data of all CABG patients from January 2004 until December 2008 were analysed. Receiver-operating characteristics (ROC) curves for the additive and logistic EuroSCOREs and the areas under the ROC curve were calculated. Predicted probability of hospital mortality was calculated using logistic regression analyses and compared with the EuroSCORE. Cumulative sum (CUSUM) analyses were performed for the EuroSCORE and the actual hospital mortality.Results. 5249 patients underwent CABG of which 89 (1.7%) died. The mean additive EuroSCORE was 3.5+/-2.5 (0-17) (median 3.0) and the mean logistic EuroSCORE was 4.0+/-5.5 (0-73) (median 2.4). The area under the ROC curve was 0.80+/-0.02 (95% confidence interval (CI) 0.76 to 0.84) for the additive and 0.81+/-0.02 (0.77 to 0.85) for the logistic EuroSCORE. The predicted probability (hazard ratio) was different from the additive and logistic EuroSCOREs. The hospital mortality was half of the EuroSCOREs, resulting in positive variable life-adjusted display curves. Conclusions. Both the additive and logistic EuroSCOREs are overestimating the in-hospital mortality risk in low-risk CABG patients. The logistic EuroSCORE is more accurate in high-risk patients compared with the additive EuroSCORE. Until a more accurate risk scoring system is available, we suggest being careful when comparing the quality of care of different centres based on risk-adjusted mortality rates. (Neth Heart J 2010;18:355-9.).

摘要

背景

风险调整死亡率被用于比较不同医院的医疗质量。我们评估了欧洲心脏手术风险评分(EuroSCORE)在接受单纯冠状动脉旁路移植术(CABG)的患者中的应用。

患者和方法

分析了 2004 年 1 月至 2008 年 12 月期间所有接受 CABG 的患者的数据。计算了加性和逻辑 EuroSCORE 的受试者工作特征(ROC)曲线和曲线下面积。使用逻辑回归分析计算预测住院死亡率的概率,并与 EuroSCORE 进行比较。对 EuroSCORE 和实际住院死亡率进行累积和(CUSUM)分析。

结果

5249 例患者接受了 CABG,其中 89 例(1.7%)死亡。平均加性 EuroSCORE 为 3.5+/-2.5(0-17)(中位数为 3.0),平均逻辑 EuroSCORE 为 4.0+/-5.5(0-73)(中位数为 2.4)。ROC 曲线下面积为加性 EuroSCORE 为 0.80+/-0.02(95%置信区间(CI)为 0.76 至 0.84),逻辑 EuroSCORE 为 0.81+/-0.02(0.77 至 0.85)。预测概率(风险比)与加性和逻辑 EuroSCORE 不同。住院死亡率为 EuroSCOREs 的一半,导致可变生命调整显示曲线呈阳性。

结论

加性和逻辑 EuroSCORE 均高估了低危 CABG 患者的住院死亡率风险。与加性 EuroSCORE 相比,逻辑 EuroSCORE 对高危患者更为准确。在更准确的风险评分系统出现之前,我们建议在基于风险调整死亡率比较不同中心的医疗质量时要小心谨慎。(荷兰心脏杂志 2010;18:355-9)。

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本文引用的文献

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Is it possible to improve the accuracy of EuroSCORE?能否提高 EuroSCORE 的准确性?
Eur J Cardiothorac Surg. 2009 Nov;36(5):799-804. doi: 10.1016/j.ejcts.2009.03.069. Epub 2009 Jun 11.
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European system for cardiac operative risk evaluation (EuroSCORE).欧洲心脏手术风险评估系统(EuroSCORE)。
Eur J Cardiothorac Surg. 1999 Jul;16(1):9-13. doi: 10.1016/s1010-7940(99)00134-7.

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