在 PhI(OAc)(2)/NaOH 存在下通过芳基迁移反应首次合成 3-芳基-4-未取代-6-CF(3)-吡啶-2-酮。
First synthesis of 3-aryl-4-unsubstituted-6-CF(3)-pyridin-2-ones via aryl migration reaction in the presence of PhI(OAc)(2)/NaOH.
机构信息
Department of Chemistry, School of Science, Shanghai University, 99 Shangda Road, Shanghai 200444, PR China.
出版信息
Chem Commun (Camb). 2010 Oct 7;46(37):6941-3. doi: 10.1039/c0cc01815e. Epub 2010 Aug 23.
PMID:20730174
Abstract
3-Aryl-4-unsubstituted-6-CF(3)-pyridin-2-ones have been efficiently synthesized from readily available 4-aryl-3-carbamoyl-6-CF(3)-pyridin-2(1H)-ones by treatment with PhI(OAc)(2) in the presence of NaOH.
摘要
3-芳基-4-未取代的 6-CF(3)-吡啶-2-酮可通过用 PhI(OAc)(2)在 NaOH 存在下处理易得的 4-芳基-3-氨甲酰基-6-CF(3)-吡啶-2(1H)-酮来高效合成。
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