Xiang Dexuan, Wang Kewei, Liang Yongjiu, Zhou Guangyuan, Dong Dewen
Department of Chemistry, Northeast Normal University, Changchun 130024, China.
Org Lett. 2008 Jan 17;10(2):345-8. doi: 10.1021/ol702846t. Epub 2007 Dec 28.
A facile and efficient one-pot synthesis of polysubstituted pyridin-2(1H)-ones from a variety of beta-oxo amides under Vilsmeier conditions is described, and a mechanism involving sequential halogenation, formylation and intramolecular nucleophilic cyclization is proposed.
描述了一种在Vilsmeier条件下从多种β-氧代酰胺简便高效地一锅合成多取代吡啶-2(1H)-酮的方法，并提出了一种涉及连续卤化、甲酰化和分子内亲核环化的机理。
