在Vilsmeier条件下，由β-氧代酰胺简便高效地合成多官能化吡啶-2(1H)-酮。
A facile and efficient synthesis of polyfunctionalized pyridin-2(1H)-ones from beta-oxo amides under Vilsmeier conditions.
作者信息
Xiang Dexuan, Wang Kewei, Liang Yongjiu, Zhou Guangyuan, Dong Dewen
机构信息
Department of Chemistry, Northeast Normal University, Changchun 130024, China.
出版信息
Org Lett. 2008 Jan 17;10(2):345-8. doi: 10.1021/ol702846t. Epub 2007 Dec 28.
PMID:18161982
Abstract
A facile and efficient one-pot synthesis of polysubstituted pyridin-2(1H)-ones from a variety of beta-oxo amides under Vilsmeier conditions is described, and a mechanism involving sequential halogenation, formylation and intramolecular nucleophilic cyclization is proposed.
摘要
描述了一种在Vilsmeier条件下从多种β-氧代酰胺简便高效地一锅合成多取代吡啶-2(1H)-酮的方法，并提出了一种涉及连续卤化、甲酰化和分子内亲核环化的机理。
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