Lopes da Silva Rodrigo, Fernandes Teresa, Lopes Alexandra, Santos Susana, Mafra Manuela, Rodrigues António Silva, de Sousa Aida Botelho
Serviço de Hematologia, Hospital Santo António dos Capuchos, Alameda Santo António dos Capuchos, 1169-050 Lisbon, Portugal.
Head Neck Pathol. 2010 Dec;4(4):318-23. doi: 10.1007/s12105-010-0206-2. Epub 2010 Aug 22.
In adults, non-Hodgkin's lymphoma (NHL) is the second most common neoplasm found in the head and neck region after squamous cell carcinoma. Within this region, primary NHL of the nasopharynx is rare. We report the case of a 28-year-old male diagnosed with a B lymphoblastic lymphoma (CD20-; CD79a+; CD3-; CD10+; PAX5+, CyclinD1-; TdT+) of the nasopharynx extending to the deep and superficial structures of the right hemiface, to the skull base with an intracranial component and a small but detectable bone marrow involvement, who was started on chemotherapy with a complete response. To the best of our knowledge, this is the first case of a primary nasopharynx B-LBL in an adult patient with such aggressive regional spread to be reported in the literature.
在成人中，非霍奇金淋巴瘤（NHL）是头颈部区域继鳞状细胞癌之后第二常见的肿瘤。在该区域内，鼻咽原发性NHL较为罕见。我们报告一例28岁男性病例，该患者被诊断为鼻咽部B淋巴母细胞淋巴瘤（CD20阴性；CD79a阳性；CD3阴性；CD10阳性；PAX5阳性；细胞周期蛋白D1阴性；末端脱氧核苷酸转移酶阳性），肿瘤已蔓延至右侧半脸的深部和浅表结构、颅底并伴有颅内成分，且有少量但可检测到的骨髓受累，患者开始化疗后获得完全缓解。据我们所知，这是文献中报道的首例成年原发性鼻咽部B淋巴母细胞淋巴瘤且出现如此侵袭性区域扩散的病例。
