Kim Ji-Yeon, Kim You Chan, Lee Eun-So
Department of Dermatology, Ajou University School of Medicine, Suwon, South Korea.
J Cutan Pathol. 2006 Sep;33(9):649-53. doi: 10.1111/j.1600-0560.2006.00405.x.
Precursor B-cell lymphoblastic lymphoma (B-LBL) is a rare neoplasm composed of immature lymphocytes that demonstrate lymphoblastic morphology and express precursor and B-cell marker. It usually affects people of younger age group and causes multiple nodules on the head and neck area. The neoplasm is rare in old age. We report a case of B-LBL occurring in a 65-year-old man. He presented with multiple skin nodules on the scalp, the neck and the arm for 2 months. Histopathologic examination demonstrated diffuse dermal and subcutaneous monotonous infiltrates of medium-sized lymphoid cells with starry-sky pattern. Immunohistochemical study showed that the lymphoid cells of infiltrate showed precursor B-cell type. The patient has received combination chemotherapy three times and is being followed-up at the outpatient clinic.
前体B细胞淋巴母细胞淋巴瘤（B-LBL）是一种罕见的肿瘤，由具有淋巴母细胞形态并表达前体和B细胞标志物的未成熟淋巴细胞组成。它通常影响较年轻年龄组的人群，并在头颈部区域引起多个结节。这种肿瘤在老年人中很少见。我们报告一例发生在一名65岁男性身上的B-LBL病例。他头皮、颈部和手臂出现多个皮肤结节2个月。组织病理学检查显示真皮和皮下有弥漫性、中等大小淋巴细胞的单调浸润，呈星空样模式。免疫组织化学研究表明浸润的淋巴细胞为前体B细胞类型。该患者已接受三次联合化疗，目前正在门诊随访。
