Amberger D M, Saleem A, Kemp B L, Truong L D
Department of Pathology, Baylor College of Medicine, Houston, TX 77030.
Ann Clin Lab Sci. 1990 Nov-Dec;20(6):409-14.
The histogenesis of blasts in acute myelofibrosis is generally regarded to be of megakaryocytic origin. Three case reports are presented and 19 other reported cases were reviewed from the literature where the cells of origin appear to be myeloblasts, myelomonoblasts, lymphoblasts, or undifferentiated blasts. It is therefore postulated that acute myelofibrosis is a hemopoietic stem cell disorder, and acute megakaryocytic leukemia (FAB-M7) represents one subset of the disorder.
急性骨髓纤维化中原始细胞的组织发生通常被认为起源于巨核细胞。本文报告了3例病例，并复习了文献中另外19例报告病例，这些病例中原始细胞的起源似乎是成髓细胞、粒-单核母细胞、淋巴母细胞或未分化的原始细胞。因此推测急性骨髓纤维化是一种造血干细胞疾病，而急性巨核细胞白血病（FAB-M7）是该疾病的一个子集。
