Sibireva O F, Khitrinskaia E Iu, Kaliuzhin V V, Kaliuzhina E V
Ter Arkh. 2010;82(6):32-4.
to study the activity of free radical processes in patients with alcoholism and renal lesion (A+RL) and the implication of depressed efficiency of the regulatory mechanisms limiting the accumulation of highly toxic products of lipid free radical oxidation (LFRO) in the development of secondary nephropathy.
Fifty-seven patients (mean age 31 +/- 2.8 years) with a 5-10 history of alcoholism who had been admitted to hospital for uncomplicated alcohol withdrawal syndrome were examined. Alcoholic renal lesion was detected in 17 (29.8%) patients. A control group comprised 20 healthy individuals. The activity of LFRO and antioxidative defense (AOD) was studied.
In patients with alcoholism, the study indicators reflecting the activity of LFRO statistically significantly exceeded those in the group of healthy individuals. These patients were found to have also suppressed mechanisms of first- and second-line AOD in the A+RL group.
LFRO activation developing in the presence of suppressed AOD seems to contribute to the development of secondary nephropathy in patients with alcoholism.
研究酒精中毒合并肾损害（A+RL）患者体内自由基过程的活性，以及限制脂质自由基氧化（LFRO）高毒性产物积累的调节机制效率降低在继发性肾病发展中的作用。
对57例（平均年龄31±2.8岁）有5至10年酗酒史、因单纯酒精戒断综合征入院的患者进行检查。17例（29.8%）患者检测出酒精性肾损害。对照组包括20名健康个体。研究了LFRO活性和抗氧化防御（AOD）。
酒精中毒患者中，反映LFRO活性的研究指标在统计学上显著高于健康个体组。在A+RL组中还发现这些患者的一线和二线AOD机制受到抑制。
在AOD受到抑制的情况下发生的LFRO激活似乎有助于酒精中毒患者继发性肾病的发展。
