负载型铱配合物催化酚类衍生物的定向邻硼化反应。
Directed ortho borylation of phenol derivatives catalyzed by a silica-supported iridium complex.
机构信息
Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan.
出版信息
Org Lett. 2010 Sep 17;12(18):3978-81. doi: 10.1021/ol101493m.
PMID:20731364
Abstract
The directed ortho borylation of phenol derivatives protected with an N,N-diethylcarbamoyl group was efficiently catalyzed by an immobilized monophosphine-Ir system, which was prepared in situ from Ir(OMe)(cod) and a silica-supported, compact phosphine. The utility of the carbamoyloxy group as a leaving group for metal-catalyzed cross-coupling reactions was demonstrated by its utilization in the synthesis of a terphenyl derivative.
摘要
N,N-二乙基碳酰胺基保护的酚类衍生物的定向邻硼化反应被一种固定化单膦-Ir 体系高效催化，该体系由[Ir(OMe)(cod)]2 和一种负载在硅胶上的、结构紧凑的膦原位制备而成。通过其在三联苯衍生物合成中的应用，证明了碳酰胺氧基作为离去基团在金属催化交叉偶联反应中的实用性。
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