Spritzer N, Medeiros C M, Spritzer T S, Medeiros N K
Instituto de Cardiologia do Rio Grande do Sul, Porto Alegre, RS.
Arq Bras Cardiol. 1990 Jul;55(1):71-4.
To evaluate the efficacy of nitrendipine 20 mg OD in mild to moderate hypertensive subjects.
Twenty patients followed for 90 days. The protocol was a double blind placebo control trial using 24 hours ambulatory blood pressure monitoring system for pressure and heart rate observations. After 15 days without any drug patients were randomly assigned to the study divided into two subgroups: one remained 30 days using placebo and the other nitrendipine. After a new 15 days washout period there was a cross over of the study groups and then other 30 days of follow-up.
The 24 hours mean systolic blood pressure decreased (p less than 0.0001) with nitrendipine (127.7 +/- 8 mmHg) in relation to placebo (139.2 +/- 8 mmHg); the mean diastolic blood pressure decreased (p less than 0.0001) with nitrendipine (84.6 +/- 4 mmHg) in relation to placebo (90.7 +/- 5 mmHg). There were no significant changes on heart rate and body weight.
Nitrendipine seems to be a safe and efficient antihypertensive agent for 24 hours blood pressure control. The drug can decrease blood pressure levels without significant changes over the circadian pattern of the 24 hours blood pressure curve and without unwanted drop of blood pressure levels.
评估每日一次服用20毫克尼群地平对轻至中度高血压患者的疗效。
20名患者接受为期90天的随访。研究方案为双盲安慰剂对照试验，使用24小时动态血压监测系统观察血压和心率。在15天未服用任何药物后，患者被随机分为两个亚组：一组服用安慰剂30天，另一组服用尼群地平。经过新的15天洗脱期后，研究组进行交叉，然后再进行30天的随访。
与安慰剂组（139.2±8mmHg）相比，尼群地平组（127.7±8mmHg）24小时平均收缩压降低（p<0.0001）；与安慰剂组（90.7±5mmHg）相比，尼群地平组（84.6±4mmHg）平均舒张压降低（p<0.0001）。心率和体重无显著变化。
尼群地平似乎是一种安全有效的24小时血压控制抗高血压药物。该药物可降低血压水平，而不会显著改变24小时血压曲线的昼夜模式，也不会导致血压水平意外下降。
