Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
J Cell Biol. 2010 Aug 23;190(4):487-9. doi: 10.1083/jcb.201007096.
In this issue, a study by Groehler and Lannigan (2010. J. Cell Biol. doi:10.1083/jcb.201002124) sheds light on the regulation of proliferating cell nuclear antigen (PCNA) turnover and how it is counteracted by the small chromatin-bound kinase ERK8 (extracellular signal-regulated kinase 8). Importantly, inactivation of ERK8 results in genome instability and is associated with cell transformation.
本期杂志中，Groehler 和 Lannigan 的研究（2010. 《细胞生物学杂志》。doi:10.1083/jcb.201002124）揭示了增殖细胞核抗原（PCNA）周转的调控机制，以及它如何被小染色质结合激酶 ERK8（细胞外信号调节激酶 8）所拮抗。重要的是，ERK8 的失活会导致基因组不稳定，并与细胞转化相关。
