Cook Jeanette Gowen
Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center Campus Box 7260, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Front Biosci (Landmark Ed). 2009 Jun 1;14(13):5013-30. doi: 10.2741/3584.
Accurate and timely duplication of chromosomal DNA requires that replication be coordinated with processes that ensure genome integrity. Significant advances in determining how the earliest steps in DNA replication are affected by DNA damage have highlighted some of the mechanisms to establish that coordination. Recent insights have expanded the relationship between the ATM and ATR-dependent checkpoint pathways and the proteins that bind and function at replication origins. These findings suggest that checkpoints and replication are more intimately associated than previously appreciated, even in the absence of exogenous DNA damage. This review summarizes some of these developments.
染色体DNA的准确及时复制要求复制过程与确保基因组完整性的过程相协调。在确定DNA损伤如何影响DNA复制的最早步骤方面取得的重大进展，凸显了建立这种协调的一些机制。最近的见解扩展了ATM和ATR依赖的检查点途径与在复制起点结合并发挥作用的蛋白质之间的关系。这些发现表明，即使在没有外源性DNA损伤的情况下，检查点和复制之间的关联也比以前认为的更为密切。本综述总结了其中的一些进展。
