Department of Neurology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
Eur Neurol. 2010;64(4):219-23. doi: 10.1159/000319605. Epub 2010 Aug 20.
BACKGROUND/AIMS: Brachial-ankle pulse wave velocity (baPWV) is a marker of vascular stiffness and is reported to be associated with diabetic neuropathy; however, the relationship between baPWV and nerve conduction study (NCS) has yet to be examined.
Between January 2006 and December 2008, we investigated this relationship in diabetic patients. To this end, we reviewed the medical records of 100 diabetic patients for whom both baPWV and NCS had been examined.
The mean age of patients was 55.4 ± 10.6 years, and the mean duration of diabetes mellitus was 6.3 ± 7.3 years. A statistically significant inverse correlation between baPWV and NCS was observed, especially in the lower extremity sensory NCS [superficial peroneal sensory nerve action potential (SNAP), r = -0.466, p <0.05; sural SNAP, r = -0.384, p <0.01]. A multiple linear regression analysis also demonstrated a significant association between baPWV and some parameters of NCS (SNAP of sural nerve, and nerve conduction velocity of peroneal and sural nerves).
These results indicate that the degree of systemic arterial stiffness is associated with peripheral nerve status in diabetic patients, but it is unclear what this signifies and further study is needed.
背景/目的：肱踝脉搏波速度（baPWV）是血管僵硬的标志物，据报道与糖尿病性神经病有关；然而，baPWV 与神经传导研究（NCS）之间的关系尚未得到检验。
在 2006 年 1 月至 2008 年 12 月期间，我们对糖尿病患者进行了这项研究。为此，我们回顾了 100 例糖尿病患者的病历，这些患者均进行了 baPWV 和 NCS 检查。
患者的平均年龄为 55.4 ± 10.6 岁，糖尿病的平均病程为 6.3 ± 7.3 年。baPWV 与 NCS 之间存在显著的负相关，尤其是在下肢感觉 NCS 中[腓浅感觉神经动作电位（SNAP），r = -0.466，p <0.05；腓肠 SNAP，r = -0.384，p <0.01]。多元线性回归分析也表明，baPWV 与 NCS 的一些参数之间存在显著关联（腓肠神经 SNAP 和腓总神经及腓肠神经的神经传导速度）。
这些结果表明，系统性动脉僵硬的程度与糖尿病患者的周围神经状况有关，但目前尚不清楚这意味着什么，需要进一步研究。
