Department of Allergology, Medical University of Gdansk, Gdansk, Poland.
Int Arch Allergy Immunol. 2011;154(2):149-54. doi: 10.1159/000320229. Epub 2010 Aug 24.
The clinical value of conjunctival allergen challenge (CAC) with latex allergen in patients with allergic conjunctivitis remains undefined. The aim of this study was to assess the value of conjunctival allergen challenge with latex extract in a group of patients with latex sensitization and a history of conjunctivitis after contact with latex products.
Fifty patients who had symptoms of conjunctivitis following contact with latex were studied. The control group consisted of 30 subjects without any symptoms of conjunctivitis, negative skin prick test and sIgE <0.35 kU/l for latex. Questionnaires on signs and symptoms, skin prick tests with latex, sIgE and CAC with latex extract were administered. The study was performed at the Department of Allergology of the Medical University of Gdansk in Poland.
CAC with latex was positive in 46 patients (92%) and in none of the control group. CAC was the most sensitive diagnostic method (92% sensitivity and 100% specificity). The sensitivity of other methods (skin prick test and sIgE) was lower: 84 and 88%, respectively. Provocation did not induce any serious adverse events.
Our study demonstrated the high sensitivity and safety of CAC with the extract of latex allergens in the diagnosis of patients with latex allergy. This method may be considered a diagnostic option in cases with uncertain diagnosis.
在过敏性结膜炎患者中进行结膜过敏原挑战（CAC）与乳胶过敏原的临床价值仍未确定。本研究旨在评估乳胶提取物结膜过敏原挑战在一组乳胶致敏且接触乳胶制品后出现结膜炎病史的患者中的价值。
研究了 50 名接触乳胶后出现结膜炎症状的患者。对照组由 30 名无任何结膜炎症状、皮肤点刺试验阴性且乳胶 sIgE<0.35 kU/l 的受试者组成。进行了关于体征和症状、乳胶皮肤点刺试验、乳胶 sIgE 和 CAC 的问卷调查。该研究在波兰格但斯克医科大学过敏科进行。
46 名患者（92%）的乳胶 CAC 阳性，对照组均为阴性。CAC 是最敏感的诊断方法（92%的灵敏度和 100%的特异性）。其他方法（皮肤点刺试验和 sIgE）的灵敏度较低：分别为 84%和 88%。激发未引起任何严重不良事件。
我们的研究表明，乳胶过敏原提取物的 CAC 在乳胶过敏患者的诊断中具有高灵敏度和安全性。在诊断不确定的情况下，该方法可以作为一种诊断选择。
