Department of Pathology, Stanford University Medical Center, Stanford, CA 94305, USA.
Adv Anat Pathol. 2010 Sep;17(5):366-73. doi: 10.1097/PAP.0b013e3181ec7428.
Sarcomas are defined as malignant neoplasms derived from mesenchymal tissues. A variety of different molecular approaches, including gene expression profiling, have identified candidate biomarkers and insights into sarcoma biology that will aid in the diagnosis and treatment of these tumors. Many gene expression profiling findings have been translated into immunohistochemical tests for diagnostic, prognostic, or predictive purposes. This review details gene expression studies done in 3 sarcomas, synovial sarcoma, gastrointestinal stromal tumor, and leiomyosarcoma.
肉瘤被定义为源自间叶组织的恶性肿瘤。包括基因表达谱分析在内的多种不同分子方法已经确定了候选生物标志物，并深入了解肉瘤生物学，这将有助于这些肿瘤的诊断和治疗。许多基因表达谱分析结果已经转化为用于诊断、预后或预测目的的免疫组织化学检测。本综述详细介绍了滑膜肉瘤、胃肠道间质瘤和平滑肌肉瘤 3 种肉瘤的基因表达研究。
