Cross A S, Kelly N M
Department of Bacterial Diseases, Walter Reed Army Institute of Research, Washington, DC 20307-5100.
FEMS Microbiol Immunol. 1990 Dec;2(5-6):245-58. doi: 10.1111/j.1574-6968.1990.tb03526.x.
Although phagocytes appear to have a redundancy of both oxidative and non-oxidative killing mechanisms, nevertheless, bacterial pathogens are still able to evade these defenses in vivo and cause lethal infection. As the mechanisms by which phagocytes function have become detailed at the molecular level, both the recognition of specific bacterial virulence determinants and their effects at specific sites in the phagocyte are also being identified. Knowledge of these interactions may permit the use of immunomodulators either to neutralize these virulence determinants or to enhance the bactericidal capabilities of the phagocyte.
尽管吞噬细胞似乎具有氧化和非氧化杀伤机制的冗余性，但细菌病原体仍能够在体内逃避这些防御并导致致命感染。随着吞噬细胞功能机制在分子水平上的详细阐明，特定细菌毒力决定因素的识别及其在吞噬细胞中特定部位的作用也正在被确定。对这些相互作用的了解可能允许使用免疫调节剂来中和这些毒力决定因素或增强吞噬细胞的杀菌能力。
