杰里迈亚·梅茨格讲座。微生物抵御吞噬细胞杀伤的机制
The Jeremiah Metzger Lecture. Microbial defenses against killing by phagocytes.
作者信息
Mandell G L, Frank M O
机构信息
Division of Infectious Diseases, University of Virginia School of Medicine, Charlottesville 22908.
出版信息
Trans Am Clin Climatol Assoc. 1992;103:199-209.
Phagocytes are a key feature of defense against microorganisms. Phagocyte function is a complex system with many intricately involved components. Each of these components provides microorganisms with a target for countermeasures against phagocytes. We have discussed examples and purported mechanisms for microbial defenses against the steps involved in killing by phagocytes. Understanding the interplay of these host and pathogen factors leads to a better understanding of both normal host defenses and pathogenesis of disease.
吞噬细胞是抵御微生物的关键要素。吞噬细胞功能是一个复杂的系统，有许多错综复杂相互关联的组成部分。这些组成部分中的每一个都为微生物提供了针对吞噬细胞的应对靶点。我们已经讨论了微生物针对吞噬细胞杀伤过程中各个步骤的防御示例及所谓机制。了解这些宿主和病原体因素之间的相互作用，有助于更好地理解正常宿主防御和疾病发病机制。
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