与 TP53 密码子 72 多态性与非霍奇金淋巴瘤风险的关联。
Association with TP53 codon 72 polymorphism and the risk of non-Hodgkin lymphoma.
出版信息
Am J Hematol. 2010 Oct;85(10):822-4. doi: 10.1002/ajh.21834.
Polymorphism of TP53 Arg72Pro is associated with many different cancers[1-4]. Few studies have investigated its role in the susceptibility to non-Hodgkin lymphoma (NHL) [5,6]. To examine the association between this polymorphism and NHL risk, we conducted a Korean large-scale, population-based case-control study (945 cases and 1,700 controls). The TP53 72CC genotype was associated with increased risk of NHL (P 5 0.04) and diffuse large B-cell lymphoma (P 5 0.04). Our findings provide evidence that the TP53 Arg72Pro is associated with an increased risk of NHL in Korea.
TP53 Arg72Pro 多态性与许多不同的癌症有关[1-4]。很少有研究探讨其在非霍奇金淋巴瘤（NHL）易感性中的作用[5,6]。为了研究这种多态性与 NHL 风险之间的关系，我们进行了一项韩国大规模、基于人群的病例对照研究（945 例病例和 1700 例对照）。TP53 72CC 基因型与 NHL（P=0.04）和弥漫性大 B 细胞淋巴瘤（P=0.04）的风险增加相关。我们的研究结果提供了证据，表明 TP53 Arg72Pro 与韩国 NHL 风险增加有关。
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