p53基因第72位密码子精氨酸突变为脯氨酸的单核苷酸多态性对印度北部人群乳腺癌风险的影响。
Impact of p53 arg72pro SNP on Breast Cancer Risk in North Indian Population.
作者信息
Akhter Naseem, Dar Sajad A, Chattopadhyay Shilpi, Haque Shafiul, Anwer Razique, Wahid Mohd, Jawed Arshad, Lohani Mohtashim, Mandal Raju K, Shukla N K, Abdul Yasir, Husain Syed Akhtar
机构信息
Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Albaha University, Albaha, Saudi Arabia.
Department of Biosciences, Faculty of Natural Sciences, Jamia Millia Islamia (A Central University), New Delhi-110025, India.
出版信息
Curr Genomics. 2018 Aug;19(5):395-410. doi: 10.2174/1389202919666171205104137.
BACKGROUND
Genetic changes in p53 gene contribute to breast cancer susceptibility.
OBJECTIVE AND METHODS
A case-control study and a meta-analysis were performed to investigate the role of p53 codon72 SNP with breast cancer susceptibility in Indian women.
RESULTS
p53 heterozygous arginine variant was associated with decreased risk of breast cancer in total cohort. In meta-analysis, Allelic and GG vs. CC genetic comparison model were found to be associated with breast cancer risk. Moreover, recessive comparison model indicated a protective correlation with breast cancer occurrence.
CONCLUSION
The findings of our case-control study and meta-analysis suggest a significant association between p53 Arg72Pro polymorphism and an increased risk of breast cancer in Indian population.
背景
p53基因的遗传变化会导致乳腺癌易感性增加。
目的与方法
进行了一项病例对照研究和荟萃分析，以调查p53密码子72单核苷酸多态性（SNP）在印度女性乳腺癌易感性中的作用。
结果
在整个队列中，p53杂合精氨酸变体与乳腺癌风险降低相关。在荟萃分析中，发现等位基因以及GG与CC基因比较模型与乳腺癌风险相关。此外，隐性比较模型表明与乳腺癌发生存在保护相关性。
结论
我们的病例对照研究和荟萃分析结果表明，p53 Arg72Pro多态性与印度人群乳腺癌风险增加之间存在显著关联。
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