Child and Adolescent Psychiatry Department, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
World J Biol Psychiatry. 2010 Dec;11(8):964-71. doi: 10.3109/15622975.2010.507785. Epub 2010 Aug 24.
To investigate and compare the rate and type of psychiatric co-morbidity in individuals with diagnosis of high functioning autism (HFA) and Asperger's disorder (AS).
This study includes 30 children and adolescents with diagnosis of HFA and 30 with diagnosis of AS. Diagnoses of HFA and AS were made using strict DSM-IV criteria. Psychiatric co-morbidity was assessed using the Schedule for Affective Disorders and Schizophrenia for School Age Children-Present and Lifetime Version (K-SADS-PL-T).
The rate of comorbid psychiatric disorders was very high in both groups (93.3% in HFA and 100% in AS). The most common disorder in both groups was attention deficit hyperactivity disorder. There was no statistically significant difference between groups in the rate of associated psychiatric disorders, except for major depressive disorder (P = 0.029) and ADHD-combined type (P = 0.030). The AS group displayed greater comorbidity with depressive disorders and ADHD-CT.
From a clinical perspective, it could be concluded that both disorders involve a high risk for developing psychiatric disorders, with AS patients at greater risk for depression. From a nosological perspective, the substantial similarities in terms of psychiatric comorbidity may support the idea that both disorders are on the same spectrum and differs in some aspects.
调查和比较高功能自闭症（HFA）和阿斯伯格综合征（AS）个体的精神共病率和类型。
本研究纳入 30 名 HFA 诊断患儿和 30 名 AS 诊断患儿。HFA 和 AS 的诊断均采用严格的 DSM-IV 标准。使用儿童青少年情感障碍和精神分裂症定式检查（K-SADS-PL-T）评估精神共病。
两组的共病精神障碍发生率均很高（HFA 组为 93.3%，AS 组为 100%）。两组最常见的共病障碍均为注意缺陷多动障碍。除了重性抑郁障碍（P=0.029）和注意缺陷多动障碍混合型（P=0.030）外，两组之间的相关精神障碍发生率无统计学差异。AS 组与抑郁障碍和 ADHD-CT 的共病率更高。
从临床角度来看，可以得出结论，这两种障碍都存在发生精神障碍的高风险，AS 患者的抑郁风险更高。从分类学的角度来看，精神共病方面的显著相似性可能支持这两种障碍在同一谱系上，在某些方面存在差异的观点。
