Valenza Giuseppe, Radike Kerstin, Schoen Christoph, Horn Stephan, Oesterlein Anett, Frosch Matthias, Abele-Horn Marianne, Hebestreit Helge
Institute of Hygiene and Microbiology, University of Würzburg, Würzburg, Germany.
Scand J Infect Dis. 2010 Dec;42(11-12):885-9. doi: 10.3109/00365548.2010.509333. Epub 2010 Aug 25.
Tobramycin and colistin represent 2 standard antimicrobial agents in the treatment of cystic fibrosis (CF) patients who are chronically colonized with Pseudomonas aeruginosa. In this study, we determined the rate of resistance to tobramycin and colistin in 1844 isolates of P. aeruginosa obtained from 22 CF patients under alternate therapy with inhaled tobramycin and colistin. Resistance to tobramycin was observed in 27.5% of isolates. In contrast, all isolates were susceptible to colistin. Molecular typing of selected isolates suggested that only 1 clone occurred over time in each patient. To conclude, resistance to tobramycin in P. aeruginosa isolates from CF patients under antimicrobial therapy may occur while colistin resistance remains uncommon.
妥布霉素和黏菌素是治疗长期感染铜绿假单胞菌的囊性纤维化（CF）患者的两种标准抗菌药物。在本研究中，我们测定了从22例接受吸入妥布霉素和黏菌素交替治疗的CF患者中分离出的1844株铜绿假单胞菌对妥布霉素和黏菌素的耐药率。27.5%的分离株对妥布霉素耐药。相比之下，所有分离株对黏菌素均敏感。对选定分离株的分子分型表明，每位患者随时间推移仅出现1个克隆。总之，接受抗菌治疗的CF患者分离出的铜绿假单胞菌对妥布霉素可能产生耐药，而黏菌素耐药仍不常见。
