临床分离株中黏菌素耐药性的流行情况：一项系统评价和荟萃分析。

Prevalence of colistin resistance in clinical isolates of : a systematic review and meta-analysis.

作者信息

Narimisa Negar, Keshtkar Abbasali, Dadgar-Zankbar Leila, Bostanghadiri Narjess, Far Yasaman Rouein, Shahroodian Soheila, Zahedi Bialvaei Abed, Razavi Shabnam

机构信息

Microbial Biotechnology Research Center, Iran University of Medical Sciences, Tehran, Iran.

Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

出版信息

Front Microbiol. 2024 Oct 9;15:1477836. doi: 10.3389/fmicb.2024.1477836. eCollection 2024.

OBJECTIVE

The emergence of resistance to colistin, the last resort for treating severe infections caused by , poses a significant threat to public health. This meta-analysis aimed to investigate the prevalence of colistin resistance in clinical isolates of

METHOD

A comprehensive search of MEDLINE (PubMed), Web of Science, and Scopus databases was conducted to identify relevant articles published until December 2023. Subsequently, a meta-analysis was performed using Stata software to examine the pooled prevalence of colistin resistance and to conduct subgroup analyses.

RESULTS

A total of 619 studies were included in the meta-analysis, revealing a global prevalence of colistin resistance of 1% among all isolates. Furthermore, cystic fibrosis patients exhibited the highest resistance to colistin, with a prevalence of 7% among the examined diseases.

CONCLUSION

The increase in colistin resistance in in recent years from 2% (in the period of 2006-2010) to 5% (in the period of 2020-2023) underscores the need for implementing infection prevention programs, using appropriate treatment regimens, and disseminating comprehensive information on antimicrobial resistance patterns. These measures are crucial for addressing this growing public health concern.